Activation of caspases in lymphocytes of patients with depression and anxiety

   
Gerasimovich E.S.1, Yakovlev A.A.2 , Druzhkova T.A.3, Grishkina M.N.3, Guekht A.B.3, Gulyaeva N.V.2

1. Lomonosov Moscow State University, Moscow, Russia
2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia; Scientific Clinical Center of Psychoneurology, Moscow, Russia
3. Scientific Clinical Center of Psychoneurology, Moscow, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166201089      PubMed Id: 26973194
Year: 2016  Volume: 62  Issue: 1  Pages: 89-92
The processes in the nervous and immune systems are closely interrelated. In particular, increased apoptosis was reported in lymphocytes of patients with depression. The aim of this study was to assess activities of proteases associated with cell death in lymphocytes of patient with personality disorders accompanied by depression and anxiety. In patients with personality disorders associated with organic brain dysfunction caspase activities were reduced in patients with depression and increased in patients with anxiety. The results may be useful for elucidation of pathogenetic mechanisms of personality disorders and in search of new biomarkers of these diseases.
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Keywords: depression, anxiety, lymphocytes, apoptosis, caspases, plasma peptides
Citation:

Gerasimovich, E. S., Yakovlev, A. A., Druzhkova, T. A., Grishkina, M. N., Guekht, A. B., Gulyaeva, N. V. (2016). Activation of caspases in lymphocytes of patients with depression and anxiety. Biomeditsinskaya khimiya, 62(1), 89-92.
This paper is also available as the English translation: 10.1134/S1990750816030021
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