Nowadays, the percentage of elderly people in society grows. Good nutrition and medical care help older people to have a normal life over 80 to 90 years. In the last ten years it is of critical importance to establish the clinical significance of serum IgG anti-GD1a and anti-GM1 ganglioside antibodies as potential biomarkers for neuronal damage in neurodegenerative diseases and immune-mediated neuropathies and demyelination. In the current study, the diagnostic values of IgG anti-GD1a and anti-GM1 antibodies were determined by the ELISA method in serum samples of 18 elderly patients (71-91 years). Significantly elevated serum IgG anti-GD1a and anti-GM1 antibodies titers were detected only in patients over 80 years. These data suggest that the immune-mediated neuropathies, neurodegeneration and demyelination in healthy elderly occur after 80 years old. Therefore, IgG anti-GD1a and anti-GM1 antibodies can serve as biomarkers, showing the nervous system dysfunction.
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Keywords: serum IgG anti-GD1a and anti-GM1 antibodies, ELISA, elderly people
Citation:
Kolyovska V. (2016) Serum igG antibodies to GD1a and GM1 gangliosides in elderly people. Biomeditsinskaya Khimiya, 62(1), 93-95.
et al. Serum igG antibodies to GD1a and GM1 gangliosides in elderly people // Biomeditsinskaya Khimiya. - 2016. - V. 62. -N 1. - P. 93-95.
et al., "Serum igG antibodies to GD1a and GM1 gangliosides in elderly people." Biomeditsinskaya Khimiya 62.1 (2016): 93-95.
Kolyovska, V. (2016). Serum igG antibodies to GD1a and GM1 gangliosides in elderly people. Biomeditsinskaya Khimiya, 62(1), 93-95.
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