Application of reporter strains for new antibiotic screening

Sergiev P.V.1 , Osterman I.A.1, Golovina A.Ya.1, Laptev I.G.1, Pletnev P.I.1, Evfratov S.A.1, Marusich E.I.2, Leonov S.V.2, Ivanenkov Ya.A.2, Bogdanov A.A.1, Dontsova O.A.1

1. Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
2. Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow region, Russia
Section: Review
DOI: 10.18097/PBMC20166202117      PubMed Id: 27143367
Year: 2016  Volume: 62  Issue: 2  Pages: 117-123
Screening for new antibiotics remains an important area of biology and medical science. Indispensable for this type of research is early identification of antibiotic mechanism of action. Preferentially, it should be studied quickly and cost-effectively, on the stage of primary screening. In this review we describe an application of reporter strains for rapid classification of antibiotics by its target, without prior purification of an active compound and determination of chemical structure
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Keywords: antibiotic, protein synthesis, bacteria, reporter strain, screening

Sergiev, P. V., Osterman, I. A., Golovina, A. Ya., Laptev, I. G., Pletnev, P. I., Evfratov, S. A., Marusich, E. I., Leonov, S. V., Ivanenkov, Ya. A., Bogdanov, A. A., Dontsova, O. A. (2016). Application of reporter strains for new antibiotic screening. Biomeditsinskaya Khimiya, 62(2), 117-123.
This paper is also available as the English translation: 10.1134/S1990750816040065
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