Epigenetic factors in atherogenesis: microRNA

   
Smirnova A.V.1 , Sukhorukov V.N.2, Karagodin V.P.3, Orekhov A.N.4

1. Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia
2. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
3. Plekhanov Russian University of Economics, Moscow, Russia
4. Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20166202134      UDK: 575.577.2:616.577.2:579      PubMed Id: 27143369
Year: 2016  Volume: 62  Issue: 2  Pages: 134-140
MicroRNAs (miRNAs) are small (~22 nucleotides in length) noncoding RNA sequences regulating gene expression at posttranscriptional level. MicroRNAs bind complementarily to certain mRNA and cause gene silencing. The involvement of miRNAs in the regulation of lipid metabolism, inflammatory response, cell cycle progression and proliferation, oxidative stress, platelet activation, endothelial and vascular smooth muscle cells (VSMC) function, angiogenesis and plaque formation and rapture indicates important roles in the initiation and progression of atherosclerosis. The key role of microRNAs in pathophysiology of cardiovascular diseases (CVDs), including atherosclerosis, was demonstrated in recent studies. Creating antisense oligonucleotides is a novel technique for selective changes in gene expression both in vitro and in vivo. In this review, we draw attention to the role of miRNAs in atherosclerosis progression, using miRNA as the potential biomarkers and targets in the CVDs, as well as possible application of antisense oligonucleotides
Download PDF:
Reference:

Smirnova A.V., Sukhorukov V.N., Karagodin V.P., Orekhov A.N. (2016) Biomeditsinskaya khimiya, 62(2), 134-140.
This paper is also available as the English translation:10.1134/S199075081603015X
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)
        

© Institute of Biomedical Chemistry, Moscow, Russia