The use of targeted transport systems for drug delivery is a promising approach to improve pharmacokinetics of drug substances, accumulation in the lesion. In this study we have obtained and characterized the pharmaceutical composition of doxorubicin in colloidal nanoparticles equipped with targeted conjugates based on folic acid and biotin with dodecylamine. The inclusion of the address fragments into colloidal nanopartical was carried out without surface and drug substance modification The accumulation of anthracycline antibiotic doxorubicin in tumor tissue was compared in Lewis lung carcinoma mouse models after intravenous administration of the composition of colloidal nanoparticles with targeted conjugates biotin-dodecylamine and folic acid-dodecylamine or free doxorubicin. It was shown that the doxorubicin accumulation in tumor tissue when administered in drug compositions with targeted fragments are 2 times higher for the folic acid-dodecylamine conjugate and 1.4 times higher for the biotin-dodecylamine conjugate
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Keywords: targeted delivery system, oncology, folic acid, biotin, dodecylamine, accumulation in the tumor
Citation:
Sanzhakov M.A., Ignatov D.V., Kostryukova L.V., Druzhilovskaya O.S., Medvedeva N.V., Prozorovskyi V.N., Ipatova O.M. (2016) The in vivo study of the medicinal composition property of doxorubicin as a part of colloidal nanoparticles with the address fragment. Biomeditsinskaya Khimiya, 62(2), 150-153.
Sanzhakov M.A. et al. The in vivo study of the medicinal composition property of doxorubicin as a part of colloidal nanoparticles with the address fragment // Biomeditsinskaya Khimiya. - 2016. - V. 62. -N 2. - P. 150-153.
Sanzhakov M.A. et al., "The in vivo study of the medicinal composition property of doxorubicin as a part of colloidal nanoparticles with the address fragment." Biomeditsinskaya Khimiya 62.2 (2016): 150-153.
Sanzhakov, M. A., Ignatov, D. V., Kostryukova, L. V., Druzhilovskaya, O. S., Medvedeva, N. V., Prozorovskyi, V. N., Ipatova, O. M. (2016). The in vivo study of the medicinal composition property of doxorubicin as a part of colloidal nanoparticles with the address fragment. Biomeditsinskaya Khimiya, 62(2), 150-153.
References
Gurram A.K., Deshpande P.B., Kar S.S., Nayak U.Y., Udupa N., Reddy M.S. (2015) Indian J. Pharm. Sci., 77, 249-257. CrossRef Scholar google search
Chauvin B., Iorga B.I., Chaminade P., Paul J.L., Maillard P., Prognon P., Kasselouri A. (2013) Eur. J. Pharm. Biopharm., 83, 244-252. CrossRef Scholar google search
Cerqueira B.B., Lasham A., Shelling A.N., Al-Kassas R. (2015) Eur. J. Pharm. Biopharm., 97(Pt A), 140-151. CrossRef Scholar google search
Watkins R., Wu L., Zhang C., Davis R.M., Xu B. (2015) Int. J. Nanomedicine, 10, 6055-6074. Scholar google search
Ipatova O.M., Zykova M.G., Prozorovskii V.N., Torkhovskaya T.I., Zakharova T.S., Possibilities for use of phospholipid nanosystem with glycyrrhizic acid ("phosphogliv") for optimization of drugs: doxorubicin and budesonide as examples, Biomeditsinskaya khimiya, 2009, vol: 55(2), 185-194. Scholar google search
Shironin A.S., Ipatova O.M., Medvedeva N.V., Prozorovskij V.N., Tixonova E.G., Torxovskaya T.I. (2012) E'fferentnaya i fiziko-ximicheskaya medicina, №1, 21-24. Scholar google search
Medvedeva N.V., Prosorovskiy V.N., Ignatov D.V., Druzilovskaya O.S., Kudinov V.A., Kasatkina E.O., Tikhonova E.G., Ipatova O.M., Pharmacological agents and transport nanosystems based on plant phospholipids, Biomeditsinskaya khimiya, 2015, vol: 61(2), 219-230. CrossRef Scholar google search
Sanzhakov M.A., Ignatov D.V., Prozorovskyi V.N., Druzhilovskaya O.S., Medvedeva N.V., Ipatova O.M., Development of targeted drug delivery system: synthesis of conjugates of address fragment (ra-cooh) with ligand (r-nh2), Biomeditsinskaya khimiya, 2014, vol: 60(6), 713-716. CrossRef Scholar google search
Russell-Jones G., McTavish K., McEwan J., Rice J., Nowotnik D. (2004) J. Inorg. Biochem., 98, 1625-1633. CrossRef Scholar google search
