The level of circulating PGC1a in cardiovascular disease

Zhloba A.A.1 , Subbotina T.F.1, Alekseevskaya E.S.1, Moiseeva O.M.2, Gavrilyuk N.D.2, Irtyuga O.B.2

1. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia; Federal Almazov Medical Research Center, Saint Petersburg, Russia
2. Federal Almazov Medical Research Center, Saint Petersburg, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166202198      PubMed Id: 27143380
Year: 2016  Volume: 62  Issue: 2  Pages: 198-205
The level of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC1a) in human blood plasma was investigated. Samples of healthy individuals (n=34) and patients with cardiovascular diseases (n=110), including aortic aneurysm (n=69), aortic stenosis (n=25) and patients without aortic pathologies were analyzed. In patients the PGC1a concentration was higher than that in healthy persons, and tended to decrease with age. Elevated concentrations of lactic acid, total homocysteine and asymmetric dimethylarginine in the blood of patients suggested a parallel development of endothelial and secondary mitochondrial dysfunction. However, concentrations of lactic and pyruvic acids exceeding reference limit were associated with the decrease in the PGC1a level
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Keywords: PGC1a, diagnostics of mitochondrial dysfunction, endothelial dysfunction, lactic acid, pyruvic acid, blood plasma

Zhloba, A. A., Subbotina, T. F., Alekseevskaya, E. S., Moiseeva, O. M., Gavrilyuk, N. D., Irtyuga, O. B. (2016). The level of circulating PGC1a in cardiovascular disease. Biomeditsinskaya Khimiya, 62(2), 198-205.
This paper is also available as the English translation: 10.1134/S1990750815020158
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