1. Department of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia; Institution of Biomedical Problems, Moscow, Russia 2. Morozov Children's Hospital, Moscow, Russia 3. Research Institute of Human Morphology of the Russian Academy of Medical Sciences, Moscow, Russia; Institution of Biomedical Problems, Moscow, Russia
Composition and quantitative content of non-esterified fatty acids (NEFA) were investigated in plasma samples of healthy children (12) and children with type 1 diabetes mellitus (DM1) (31) by gas chromatography (GC) after preliminary NEFA solid-phase extraction from plasma lipids. There was a significant (p<0.001) 1.6-fold increase in the total level of NEFA regardless of the disease duration. In the group of DM1 children with the disease period less than 1 year there was an increase in the arachidonic acid (20:4) content (30%) and the oleic acid trans-isomer (18:1) content (82%), and also a decrease in the docosahexaenoic acid (22:6 n3) content (26% ) and the docosapentaenoic acids (22:5 n-6) content (60%). In the group of DM1 children with prolonged course of this disease the altered NEFA levels returned to the normal level
Akmurzina V.A., Petryairina E.E., Saveliev S.V., Selishcheva A.A. (2016) The profile of plasma non-esterified fatty acids in children with different terms of type 1 diabetes mellitus. Biomeditsinskaya Khimiya, 62(2), 206-211.
Akmurzina V.A. et al. The profile of plasma non-esterified fatty acids in children with different terms of type 1 diabetes mellitus // Biomeditsinskaya Khimiya. - 2016. - V. 62. -N 2. - P. 206-211.
Akmurzina V.A. et al., "The profile of plasma non-esterified fatty acids in children with different terms of type 1 diabetes mellitus." Biomeditsinskaya Khimiya 62.2 (2016): 206-211.
Akmurzina, V. A., Petryairina, E. E., Saveliev, S. V., Selishcheva, A. A. (2016). The profile of plasma non-esterified fatty acids in children with different terms of type 1 diabetes mellitus. Biomeditsinskaya Khimiya, 62(2), 206-211.
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