Antiviral action and pathogenetic targets for seaweed sulfated polysaccharides in herpesvirus infections

Besednova N.N.1 , Makarenkova I.D.1, Zvyagintseva T.N.2, Imbs T.I.2, Somova L.M.1, Zaporozhets T.S.1

1. Somov Scientific Research Institute of Epidemiology and Microbiology, Vladivostok, Russia
2. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia
Section: Review
DOI: 10.18097/PBMC20166203217      UDK: 577.114: 582.232: 578.825.11      PubMed Id: 27420612
Year: 2016  Volume: 62  Issue: 3  Pages: 217-227
The review summarizes results of studies of effects of sulfated polysaccharides from seaweed on herpesviruses and the course of herpesvirus infections. Importance of this problem is determined by the prevalence of herpesviruses that can persist in the human body and demonstrate a high degree of immune mimicry and resistance to antiviral agents. A wide range of physiological action of sulfated polysaccharides, receptor agonists of innate and adaptive immune cells, which possess potent antiviral, antioxidant and anti-inflammatory activities, open the possibility of their use for creation of new generation pharmacological substances and agents with associated activity for the treatment of herpesvirus infections.
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Besednova N.N., Makarenkova I.D., Zvyagintseva T.N., Imbs T.I., Somova L.M., Zaporozhets T.S. (2016) Biomeditsinskaya khimiya, 62(3), 217-227.
This paper is also available as the English translation:10.1134/S1990750816010029
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