Protective action figurations for superoxide dismutase - chondroitin sulfate - catalase bienzyme conjugate after its medicative administration in endotoxin shock

   
Maksimenko A.V.1 , Vavaeva A.V.1, Zvyagintseva M.A.1, Abramov A.A.1, Timoshin A.A.1, Vavaev A.V.1, Lakomkin V.L.1

1. Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20166203295      PubMed Id: 27420622
Year: 2016  Volume: 62  Issue: 3  Pages: 295-301
Previously it found that the bienzymatic conjugate superoxide dismutase-chondroitin sulfate, catalase (SOD-CHS-CAT) increased the survival rate of rats with endotoxic shock caused by the administration of lipopolysaccharide (LPS). This effect was observed both in preventive (before LPS) and therapeutic conjugate administration (after the administration of LPS). This study shows that the development of endotoxic shock is accompanied by increased levels of NO in the liver, lungs, kidneys, heart; administration of the SOD-CHS-CAT conjugate insignificantly influenced this parameter. At the same time, the changes in blood urea and creatinine suggest the protective effect of the conjugate on renal function, while diverse changes in biochemical parameters studied complicate the formation of the agreed conclusions on the state of other organs.
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Keywords: oxidative stress, endotoxin shock, bienzyme superoxide dismutase-chondroitin sulphate-catalase conjugate, antioxidant enzyme therapy
Citation:

Maksimenko, A. V., Vavaeva, A. V., Zvyagintseva, M. A., Abramov, A. A., Timoshin, A. A., Vavaev, A. V., Lakomkin, V. L. (2016). Protective action figurations for superoxide dismutase - chondroitin sulfate - catalase bienzyme conjugate after its medicative administration in endotoxin shock. Biomeditsinskaya khimiya, 62(3), 295-301.
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