The increase in receptor-mediated endocytosis of drugs in the composition of nanoparticles with the address fragment

   
Kostryukova L.V.1, Sanzhakov M.A.1, Ignatov D.V.1, Prozorovskyi V.N.1, Druzhilovskaya O.S.1, Kasatkina E.S.1, Medvedeva N.V.1, Ipatova O.M.1

1. Institute of Biomedical Chemistry, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20166203306      PubMed Id: 27420624
Year: 2016  Volume: 62  Issue: 3  Pages: 306-310
It is known that disorders in the cell functioning of the organs/tissues is accompanied by increased expression of certain receptors. A modern approach to improve the specificity of the drug accumulation in the affected area is to construct the delivery nanosystems with the address fragments. Active tagged transport may help to reduce the dose of the drug, minimizing the impact on healthy cells and organs (reduced adverse events). This approach is particularly important in oncology because of the high toxicity of the drugs used. In this work we have obtained and characterized the pharmaceutical composition of doxorubicin and chlorine e6 into colloidal nanoparticles with synthesized previously targeted conjugates based on folic acid and biotin. On the cell culture Hep G2 it was shown an increase in the internalization of drugs when they were introduced in the incubation medium in the form of drug compositions with transport nanosystems and targeted fragments.
Download PDF:
Keywords: targeted delivery system, Hep G2, folic acid, biotin, intracellular internalization
Citation:

Kostryukova, L. V., Sanzhakov, M. A., Ignatov, D. V., Prozorovskyi, V. N., Druzhilovskaya, O. S., Kasatkina, E. S., Medvedeva, N. V., Ipatova, O. M. (2016). The increase in receptor-mediated endocytosis of drugs in the composition of nanoparticles with the address fragment. Biomeditsinskaya khimiya, 62(3), 306-310.
References  
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)