Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection

   
Dukova O.A.1, Kotlovsky M.Yu.2, Pokrovsky A.A.3, Suvorova E.V.4, Shivrina T.G.5, Krasnov E.A.6 , Efremov A.A.7

1. Siberian Federal University, Krasnoyarsk, Russia; Krasnoyarsk Regional Bureau of Forensic Medical Expertise, Krasnoyarsk, Russia
2. Central Research Laboratory Voyno-Yasenetsky Krasnoyarsk Medical University, Krasnoyarsk, Russia
3. Siberian Federal University, Krasnoyarsk, Russia; Central Research Laboratory Voyno-Yasenetsky Krasnoyarsk Medical University, Krasnoyarsk, Russia
4. Krasnoyarsk Regional Bureau of Forensic Medical Expertise, Krasnoyarsk, Russia
5. Karpovich Municipal Clinical Emergency Hospital № 6., Krasnoyarsk, Russia
6. Siberian Medical University, Tomsk, Russia
7. Siberian Federal University, Krasnoyarsk, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166203325      PubMed Id: 27420627
Year: 2016  Volume: 62  Issue: 3  Pages: 325-330
A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has been used for diagnostics of acute baclofen poisoning in patients.
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Keywords: baclofen, poisoning, diagnostics, HPLC-MS/MS
Citation:

Dukova, O. A., Kotlovsky, M. Yu., Pokrovsky, A. A., Suvorova, E. V., Shivrina, T. G., Krasnov, E. A., Efremov, A. A. (2016). Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection. Biomeditsinskaya khimiya, 62(3), 325-330.
This paper is also available as the English translation: 10.1134/S1990750815020067
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