Association of fatty acid metabolism with systemic inflammatory response in chronic respiratory diseases

Denisenko Y.K.1 , Novgorodtseva T.P.1, Zhukova N.V.2, Antonuk M.V.1, Lobanova E.G.1, Kalinina E.P.1

1. Vladivostok Branch of the Far Eastern Scientific Centre of Physiology and Pathology of Respiration - Institute of Medical Climatology and Rehabilitation, Vladivostok, Russia
2. Zhirmunsky Institute of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia; School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166203341      PubMed Id: 27420629
Year: 2016  Volume: 62  Issue: 3  Pages: 341-347
We examined composition of plasma non-esterified fatty acids (NFAs), erythrocyte fatty acids, levels of eicosanoids in patients with asthma and chronic obstructive pulmonary disease (COPD) with different type of the inflammatory response. The results of our study show that asthma and COPD in remission are associated with changes in the composition NFAs of plasma, FA of erythrocytes, level eicosanoid despite the difference in the regulation of immunological mechanisms of systemic inflammation. These changes are characterized by excessive production of arachidonic acid (20:4n-6) and cyclooxygenase and lipoxygenase metabolites (thromboxane B2, leukotriene B4) and deficiency of their functional antagonist, eicosapentaenoic acid (20:5n-3). The recognized association between altered fatty acid composition and disorders of the immune mechanisms of regulation of systemic inflammation in COPD and asthma demonstrated the important role of fatty acids and their metabolites in persistence of inflammatory processes in diseases of the respiratory system in the condition of remission.
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Keywords: fatty acid, metabolism, eicosanoids, systemic inflammation, respiratory disease

Denisenko, Y. K., Novgorodtseva, T. P., Zhukova, N. V., Antonuk, M. V., Lobanova, E. G., Kalinina, E. P. (2016). Association of fatty acid metabolism with systemic inflammatory response in chronic respiratory diseases. Biomeditsinskaya Khimiya, 62(3), 341-347.
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