1. Pirogov Russian National Research Medical University, Moscow, Russia 2. Serbsky Federal Medical Research Center for Narcology and Psychiatry, Moscow, Russia 3. Engelhardt institute of molecular biology RAS, Moscow, Russia 4. Pirogov Russian National Research Medical University, Moscow, Russia; Serbsky Federal Medical Research Center for Narcology and Psychiatry, Moscow, Russia
Effective treatment of malignant brain tumors is still an open problem. Location of tumor in vital areas of the brain significantly limits capasities of surgical treatment. The presence of tumor stem cells resistant to radiation and anticancer drugs in brain tumor complicates use of chemoradiotherapy and causes a high rate of disease recurrence. A technological improvement in bioselection and production of recombinant resulted in creation of viruses with potent oncolytic properties against glial tumors. Recent studies, including clinical trials, showed, that majority of oncolytic viruses are safe. Despite the impressive results of the viral therapy in some patients, the treatment of other patients is not effective; therefore, further improvement of the methods of oncolytic virotherapy is necessary. High genetic heterogeneity of glial tumor cells even within a single tumor determines differences in individual sensitivity of tumor cells to oncolytic viruses. This review analyses the most successful oncolytic virus strains, including those which had reached clinical trials, and discusses the prospects for new approaches to virotherapy of gliomas.
Sosnovtceva A.O. et al. Oncolytic viruses for therapy of malignant glioma // Biomeditsinskaya Khimiya. - 2016. - V. 62. -N 4. - P. 376-390.
Sosnovtceva A.O. et al., "Oncolytic viruses for therapy of malignant glioma." Biomeditsinskaya Khimiya 62.4 (2016): 376-390.
Sosnovtceva, A. O., Grinenko, N. F., Lipatova, A. V., Chumakov, P. M., Chekhonin, V. P. (2016). Oncolytic viruses for therapy of malignant glioma. Biomeditsinskaya Khimiya, 62(4), 376-390.
Ulasov I.V., Tyler M.A., Zheng S., Han Y., Lesniak M.S. (2006) Human Gene Ther., 17(5), 556-564. CrossRef Scholar google search
Phuong L.K., Allen C., Peng K.W., Giannini C., Greiner S., TenEyck C.J., Mishra P.K., Macura S.I., Russell S.J., Galanis E.C. (2003) Cancer Res., 63(10), 2462-2469. Scholar google search
Allen C., Opyrchal M., Aderca I., Schroeder M.A., Sarkaria J.N., Domingo E., Federspiel M.J., Galanis E. (2013) Gene Ther., 20(4), 444-449. CrossRef Scholar google search
Allen C., Vongpunsawad S., Nakamura T., James C.D., Schroeder M., Cattaneo R., Giannini C., Krempski J., Peng K.-W., Goble J.M., Uhm J.H., Russell S.J., Galanis E. (2006) Cancer Res., 66(24), 11840-11850. CrossRef Scholar google search
Allen C., Paraskevakou G., Iankov I., Giannini C., Schroeder M., Sarkaria J., Schroeder M., Puri R.K., Russell S.J.,Galanis E. (2008)Mol. Ther., 16(9), 1556-1564. CrossRef Scholar google search
Myers R., Harvey M., Kaufmann T.J., Greiner S.M., Krempski J.W., Raffel C., Shelton S.E., Soeffker D., Zollman P., Federspiel M.J., Blanco M., Galanis E. (2008) Human Gene Ther., 19(7), 690-698. CrossRef Scholar google search
Mrkic B., Pavlovic J., Rülicke T., Volpe P., Buchholz C.J., Hourcade D., Atkinson J.P., Aguzzi A., Cattaneo R. (1998) J. Virol., 72 (9) 7420-7427. Scholar google search
Driesse M.J., Vincent A.J., Sillevis S.P., Kros J.M., Hoogerbrugge P.M., Avezaat C.J., Valerio D., Bout A. (1998) Gene Ther., 5(8), 1122-1129. CrossRef Scholar google search
McCart J.A., Ward J.M., Lee J., Hu Y., Alexander H.R., Libutt S.K., Moss B., Bartlett D.L. (2001) Cancer Res., 61(24), 8751-8757. Scholar google search
Lun X.Q. Jang J.H., Tang N., Deng H., Head R., Bell J.C., Stojdl D.F., Nutt C.L., Senger D.L., Forsyth P.A., McCart J.A. (2009) Clin. Cancer Res., 15(8), 2777-2788. CrossRef Scholar google search
Lun X.Q., Chan J., Zhou H., Sun B., Kelly J.J., Stechishin O.O., Bell J.C., Parato K., Hu K., Vaillant D. et al. (2010) Mol. Ther., 18(11), 1927-1936. CrossRef Scholar google search
Gromeier M., Gromeier M., Lachmann S., Rosenfeld M.R., Gutin P.H., Wimmer E. (2000) Proc. Natl. Acad. Sci. USA, 97(12), 6803-6808. CrossRef Scholar google search
Norman K.L., Norman K.L., Hirasawa K., Yang A.D., Shields M.A., Lee P.W. (2004) Proc. Natl. Acad. Sci. USA, 101(30), 11099-11104. CrossRef Scholar google search
Wilcox M.E., Yang W., Senger D., Rewcastle N.B., Morris D.G., Brasher P.M., Shi Z.Q., Johnston R.N., Nishikawa S., Lee P.W.K., Forsyth P.A. (2001) J. Natl. Cancer Inst., 93(12), 903-912. CrossRef Scholar google search
Jebar A., West E., Scott K., Thomson S., Corns R., Mathew R., SivaKumar G., Coffey M., Nuovo G., Rose A. et al. (2014) Neuro-oncology, 16(6), art.no. P12, p.6. Scholar google search
Keshelava V.V. (2007) Epidemiologiya i vaktsinoprofilaktika, 3, 23-28. Scholar google search
Reichard K.W., Lorence R.M., Cascino C.J., Peeples M.E., Walter R.J., Fernando M.B., Reyes H.M., Greager J.A. (1992) J. Surg. Res., 52(5), 448-453. CrossRef Scholar google search
Schulze W., Kemmner J., Weitz K.-D., Schirrmacher V., Schlag P.M. (2009) Cancer Immunol. Immunother., 58, 61-69. CrossRef Scholar google search
Jeuken J., van den Broecke C., Gijsen S., Boots-Sprenger S., Wesseling P. (2007) Acta Neuropathologica, 114(2), 121-133. CrossRef Scholar google search
Zulkifli M.M., Ibrahim R., Ali A.M., Aini I., Jaafar H., Hilda S.S., Alitheen N.B., Abdullah J.M. (2009) Neurol. Res., 31, 3-10. CrossRef Scholar google search
Freeman A.I., Zakay-Rones Z., Gomori J.M., Linetsky E., Rasooly L., Greenbaum E., Rozenman-Yair S., Panet A., Libson E., Irving C.S., Galun E., Siegal T. (2006) Mol. Ther., 13(1), 221-228. CrossRef Scholar google search
Lun X., Yang, W., Alain T., Shi Z.Q., Muzik H., Barrett J.W., Forsyth P.A. (2005) Cancer Res., 65(21), 9982-9990. CrossRef Scholar google search
Lun X.Q., Alain T., Zemp F.J., Zhou H., Rahman M.M., Hamilton M.G., McFadden J., Bell J., Senger D., Forsyth P.A. (2010) Cancer Res., 70(2), 598-608. CrossRef Scholar google search
Zemp F.J., Lun X., McKenzie B.A., Zhou H., Maxwell L., Sun B., Kelly J.P., Stechishin O., Luchman A., Weiss S. et al. (2013) Neuro-oncology, 15(7), 904-920. CrossRef Scholar google search
Pisklakova A., McKenzie B., Kenchappa R., McFadden G., Forsyth P. (2014) Neuro-oncology, 16(5), art.no. E46, p 89. Scholar google search
Lun X.Q., Senger D.L., Alain T., Oprea A., Parato K., Stojdl D., Lichty B., Power A., Johnston R.N., Hamilton M., Parney I., Bell C. Jr., Forsyth P.A. (2006) J. Natl. Cancer Inst., 98(21), 1546-1557. CrossRef Scholar google search
Di Piazza M., Mader C., Geletneky K., Calle M.H., Weber E., Schlehofer J., Deleu L., Rommelaere J. (2007) J. Virol., 81(8), 4186-4198. CrossRef Scholar google search
Geletneky K., Huesing J., Rommelaere J., Schlehofer J.R., Leuchs B., Dahm M., Krebs O., von Knebel D.M., Huber B., Hajda J. (2012) BMC Cancer, 12(1), 99-107. CrossRef Scholar google search
Geletneky K., Angelova A., Leuchs B., Bhat R., Just A., Capper D., Krebs O., Dahm M., Huber B., Unterberg A., Hajda J., Rommelaere J. (2014) Neuro-oncology, 16(5), art. no. ET21, p 83-84. Scholar google search
Martuza R.L., Malick A., Markert J.M., Ruffner K.L., Coen D.M. (1991) Science, 252(5007), 854-856. CrossRef Scholar google search
Coen D.M., Kosz-Vnenchak M., Jacobson J.G., Leib D.A., Bogard C.L., Schaffer P.A., Tyler K.L., Knipe D.M. (1989) Proc. Natl. Acad. Sci. USA, 86(12), 4736-4740. CrossRef Scholar google search
Smith K.D., Mezhir J.J., Bickenbach K., Veerapong J., Charron J., Posner M.C., Roizman B., Weichselbaum R.R. (2006) J. Virol., 80(3), 1110-1120. CrossRef Scholar google search
Harrow S., Papanastassiou V., Harland J., Mabbs R., Petty R., Fraser M., Hadley D., Patterson J., Brown S.M., Rampling R. (2004) Gene Ther., 11(22), 1648-1658. CrossRef Scholar google search
Rampling R., Cruickshank G., Papanastassiou V., Nicoll J., Hadley D., Brennan D., Petty R., MacLean A., Harland J., McKie E., Mabbs R., Brown M. (2000) Gene Ther., 7(10), 859-866. CrossRef Scholar google search
Wakimoto H., Kesari S., Farrell C.J., Curry W.T., Zaupa C., Aghi M., Kuroda T., Stemmer-Rachamimov A., Shah K., Ta-Chiang Liu, Jeyaretna D.S., Debasitis J., Pruszak J., Martuza R.L., Rabkin S.D. (2009) Cancer Res., 69(8), 3472-3481. CrossRef Scholar google search
Cheema T.A., Kanai R., Kim G.W., Wakimoto H., Passer B., Rabkin S.D., Martuza R.L. (2011) Clin. Cancer Res., 17(23), 7383-7393. CrossRef Scholar google search
Cheema T.A., Wakimoto H., Fecci P.E., Ning J., Kuroda T., Jeyaretna D.S., Martuza R.L., Rabkin S.D. (2013) Proc. Natl. Acad. Sci. USA, 110(29), 12006-12011. CrossRef Scholar google search
Todo T., Tanaka M., Ito M., Ito H., Ino Y. (2014) Neuro-oncology, 16(3), pp. 52. Scholar google search
Geoerger B., Grill J., Opolon P., Morizet J., Aubert G., Terrier-Lacombe M.J., Bressac de-Paillerets B., Barrois M., Feunteun J., Kirn D.H., Vassal G. (2002) Cancer Res., 62(3), 764-772. Scholar google search
Geoerger B., Grill J., Opolon P., Morizet J., Aubert G., Lecluse Y., van Beusechem V.W., Gerritsen W.R., Kirn D.H., Vassal G. (2003) Br J. Cancer, 89(3), 577-584. CrossRef Scholar google search
Fueyo J., Gomez-Manzano C., Alemany R., Lee P.S., McDonnell T.J., Mitlianga P., Shi Y.-X., Levin V.A., Yung W.K.A., Kyritsis A.P. (2000) Oncogene, 19, 2-12. CrossRef Scholar google search
Lamfers M.L., Grill J., Dirven C.M., van Beusechem V.W., Geoerger B., van den Berg J., Alemany R., Fueyo J., Curiel D.T., Vassal G., Pinedo H.M., Vandertop W.P., Gerritsen W.R. (2002) Cancer Res., 62(20), 5736-5742. Scholar google search
Lang F.F., Conrad C., Gomez-Manzano C., Tufaro F., Sawaya R., Weinberg J., Prabhu S., Fuller G. (2014) Neuro-oncology, 16(5), art. no. NT18, pp. 162. Scholar google search
Conrad C., Miller C.R., Ji Y., Gomez-Manzano C., Bharara S., McMurray J.S., Lang F.F, Wong F., Sawaya R., Yung W.K.A., Fueyo J. (2005) Cancer Gene Ther., 12(3), 284-294. CrossRef Scholar google search
Ulasov I.V., Zhu Z.B., Tyler M.A., Han Y., Rivera A.A., Khramtsov A., Curiel D.T., Lesniak M.S. (2007) Human Gene Ther., 18(7), 589-602. CrossRef Scholar google search
Ulasov I.V., Rivera A.A., Sonabend A.M., Sonabend A.M., Wang M., Zhu Z.B., Lesniak M.S., Rivera L.B. (2007) Cancer Biol. Ther., 6(5), 679-685. CrossRef Scholar google search
Phillips J.J., Huillard E., Robinson A.E., Ward A., Lum D.H., Polley M.Y., Rosen S.D., Rowitch D.H., Werb Z. (2012) J. Clin. Invest., 122(3), 911-922. CrossRef Scholar google search
Tyler M.A., Ulasov I.V., Sonabend A.M., Nandi S., Han Y., Marler S., Roth J., Lesniak M.S. (2009) Gene Ther., 16(2), 262-278. CrossRef Scholar google search
Ahmed A.U., Thaci B., Alexiades N.G., Han Y., Qian S., Liu F., Balyasnikov I.V., Ulasov I.V., Aboody K.S., Lesniak M.S. (2011) Mol. Ther., 19(9), 1714-1726. CrossRef Scholar google search
Yong R.L., Shinojima N., Fueyo J., Gumin J., Vecil G.G., Marini F.C., Bogler O., Andreeff M., Lang F.F. (2009) Cancer Res., 69(23), 8932-8940. CrossRef Scholar google search
Giannini C., et Sarkaria J.N., Saito A., Uhm J.H., Galanis E., Carlson B.L., Schroeder M., James C.D. (2005) Neuro-oncology, 7(2), 164. CrossRef Scholar google search
Ganesh S., Gonzalez Edick M., Idamakanti N., Abramova M., Vanroey M., Robinson M., Yun C.-O., Jooss K. (2007) Cancer Res., 67, 4399-4407. CrossRef Scholar google search
Cho W.K., Seong Y.R., Lee Y.H., Kim M.J., Hwang K.S., Yoo J., Choi S., Jung C.-R., Im D.S. (2004) Mol. Ther., 10(5), 938-949. CrossRef Scholar google search
