Atherogenic modification of low-density lipoproteins
Sukhorukov V.N.1 , Karagodin V.P.2, Orekhov A.N.3
1. Institute of General Pathology and Pathophysiology, Moscow, Russia 2. Plekhanov Russian University of Economics, Moscow, Russia 3. Institute of General Pathology and Pathophysiology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, PO Box #21, Moscow, Russia
One of the first manifestations of atherosclerosis is accumulation of extra- and intracellular cholesterol esters in the arterial intima. Formation of foam cells is considered as a trigger in the pathogenesis of atherosclerosis. Low density lipoprotein (LDL) circulating in human blood is the source of lipids accumulated in the arterial walls. This review considered features and role in atherogenesis different modified forms of LDL: oxidized, small dense, electronegative and especially desialylated LDL. Desialylated LDL of human blood plasma is capable to induce lipid accumulation in cultured cells and it is atherogenic. LDL possesses numerous alterations of protein, carbohydrate and lipid moieties and therefore can be termed multiple-modified LDL. Multiple modification of LDL occurs in human blood plasma and represents a cascade of successive changes in the lipoprotein particle: desialylation, loss of lipids, reduction in the particle size, increase of surface electronegative charge, etc. In addition to intracellular lipid accumulation, stimulatory effects of naturally occurring multiple-modified LDL on other processes involved in the development of atherosclerotic lesions, namely cell proliferation and fibrosis, were shown.
Sukhorukov V.N. et al. Atherogenic modification of low-density lipoproteins // Biomeditsinskaya Khimiya. - 2016. - V. 62. -N 4. - P. 391-402.
Sukhorukov V.N. et al., "Atherogenic modification of low-density lipoproteins." Biomeditsinskaya Khimiya 62.4 (2016): 391-402.
Sukhorukov, V. N., Karagodin, V. P., Orekhov, A. N. (2016). Atherogenic modification of low-density lipoproteins. Biomeditsinskaya Khimiya, 62(4), 391-402.
References
Matsuura E., Atzeni F., Sarzi-Puttini P., Turiel M., Lopez L.R., Nurmohamed M.T. (2014) BMC Med, 12, 47. CrossRef Scholar google search
Stephen S.L., Freestone K., Dunn S., Twigg M.W., Homer-Vanniasinkam S., Walker J.H., Wheatcroft S.B., Ponnambalam S. (2010) Int. J. Hypertens, 2010, 646929. CrossRef Scholar google search
Kreuzer J., White A.L., Knott T.J., Jien M.L., Mehrabian M., Scott J., Young S.G., Haberland M.E. (1997) J. Lipid. Res., 38(2), 324-342. Scholar google search
Trpkovic A., Resanovic I., Stanimirovic J., Radak D., Mousa S.A., Cenic-Milosevic D., Jevremovic D., Isenovic E.R. (2015) Crit. Rev. Clin. Lab. Sci., 52(2), 70-85. CrossRef Scholar google search
Fukuchi M., Watanabe J., Kumagai K., Baba S., Shinozaki T., Miura M., Kagaya Y., Shirato K. (2002) Lab Invest, 82(10), 1437-1447. CrossRef Scholar google search
Napoli C., D'Armiento F.P., Mancini F.P., Postiglione A., Witztum J.L., Palumbo G., Palinski W. (1997) J. Clin. Invest, 100(11), 2680-2690. CrossRef Scholar google search
Orekhov A.N., Ivanova E.A., Bobryshev Y.V. (2015) Blood Lipids and Lipoproteins, (Ruiz M., ed.), Nova Science Publishers Inc., pp. 13-54. Scholar google search
Musunuru K., Orho-Melander M., Caulfield M.P., Li S., Salameh W.A., Reitz R.E., Berglund G., Hedblad B., Engstrom G., Williams P.T., Kathiresan S., Melander O., Krauss R.M. (2009) Arterioscler. Thromb. Vasc. Biol., 29(11), 1975-1980. CrossRef Scholar google search
Musunuru K., Strong A., Frank-Kamenetsky M., Lee N.E., Ahfeldt T., Sachs K.V., Li X., Li H., Kuperwasser N., Ruda V.M. et al. (2010) Nature, 466(7307), 714-719. CrossRef Scholar google search
Packard C., Caslake M., Shepherd J. (2000) Int. J. Cardiol., 74 Suppl 1, S17-22. Scholar google search
Chen C.H., Jiang T., Yang J.H., Jiang W., Lu J., Marathe G.K., Pownall H.J., Ballantyne C.M., McIntyre T.M., Henry P.D., Yang C.Y. (2003) Circulation, 107(16), 2102-2108. CrossRef Scholar google search
Yang C.Y., Raya J.L., Chen H.H., Chen C.H., Abe Y., Pownall H.J., Taylor A.A., Smith C.V. (2003) Arterioscler. Thromb. Vasc. Biol., 23(6), 1083-1090. CrossRef Scholar google search
Tang D., Lu J., Walterscheid J.P., Chen H.H., Engler D.A., Sawamura T., Chang P.Y., Safi H.J., Yang C.Y., Chen C.H. (2008) J. Lipid. Res., 49(1), 33-47. CrossRef Scholar google search
Chan H.C., Ke L.Y., Chu C.S., Lee A.S., Shen M.Y., Cruz M.A., Hsu J.F., Cheng K.H., Chan H.C., Lu J., Lai W.T., Sawamura T., Sheu S.H., Yen J.H., Chen C.H. (2013) Blood, 122(22), 3632-3641. CrossRef Scholar google search
Chang P.Y., Chen Y.J., Chang F.H., Lu J., Huang W.H., Yang T.C., Lee Y.T., Chang S.F., Lu S.C., Chen C.H. (2013) Cardiovasc. Res., 99(1), 137-145. Scholar google search
Parasassi T., De Spirito M., Mei G., Brunelli R., Greco G., Lenzi L., Maulucci G., Nicolai E., Papi M., Arcovito G., Tosatto S.C., Ursini F. (2008) FASEB J, 22(7), 2350-2356. CrossRef Scholar google search
Brunelli R., Balogh G., Costa G., De Spirito M., Greco G., Mei G., Nicolai E., Vigh L., Ursini F., Parasassi T. (2010) Biochemistry, 49(34), 7297-7302. CrossRef Scholar google search
Parasassi T., Bittolo-Bon G., Brunelli R., Cazzolato G., Krasnowska E.K., Mei G., Sevanian A., Ursini F. (2001) Free Radic. Biol. Med., 31(1), 82-89. CrossRef Scholar google search
Benitez S., Sanchez-Quesada J.L., Lucero L., Arcelus R., Ribas V., Jorba O., Castellvi A., Alonso E., Blanco-Vaca F., Ordonez-Llanos J. (2002) Atherosclerosis, 160(1), 223-232. CrossRef Scholar google search
Urata J., Ikeda S., Koga S., Nakata T., Yasunaga T., Sonoda K., Koide Y., Ashizawa N., Kohno S., Maemura K. (2012) Heart Vessels, 27(3), 235-242. CrossRef Scholar google search
Lu J., Yang J.H., Burns A.R., Chen H.H., Tang D., Walterscheid J.P., Suzuki S., Yang C.Y., Sawamura T., Chen C.H. (2009) Circ. Res., 104(5), 619-627. CrossRef Scholar google search
Chu C.S., Wang Y.C., Lu L.S., Walton B., Yilmaz H.R., Huang R.Y., Sawamura T., Dixon R.A., Lai W.T., Chen C.H., Lu J. (2013) PLoS One, 8(8), e70533. CrossRef Scholar google search
Greco G., Balogh G., Brunelli R., Costa G., De Spirito M., Lenzi L., Mei G., Ursini F., Parasassi T. (2009) Biophys. J., 97(2), 628-635. CrossRef Scholar google search
Benitez S., Camacho M., Bancells C., Vila L., Sanchez-Quesada J.L., Ordonez-Llanos J. (2006) Biochim. Biophys. Acta, 1761(9), 1014-1021. CrossRef Scholar google search
Sanchez-Quesada J.L., Camacho M., Anton R., Benitez S., Vila L., Ordonez-Llanos J. (2003) Atherosclerosis, 166(2), 261-270. CrossRef Scholar google search
Schauer R., Srinivasan G.V., Wipfler D., Kniep B., Schwartz-Albiez R. (2011) Adv. Exp. Med. Biol., 705, 525-548. CrossRef Scholar google search
Monti E., Bonten E., D'Azzo A., Bresciani R., Venerando B., Borsani G., Schauer R., Tettamanti G. (2010)Adv. Carbohydr. Chem. Biochem., 64, 403-479. CrossRef Scholar google search
Tanaga K., Bujo H., Inoue M., Mikami K., Kotani K., Takahashi K., Kanno T., Saito Y. (2002) Arterioscler. Thromb. Vasc. Biol., 22(4), 662-666. CrossRef Scholar google search
Cao W., Bobryshev Y.V., Lord R.S., Oakley R.E., Lee S.H., Lu J. (2003) Cardiovasc. Res., 60(1), 175-186. CrossRef Scholar google search
Shoibonov B.B., Baronets V.Y., Ontoboev A.N., Panchenko L.F. (2013) Pathogenesis, 11(2), 51-57. Scholar google search
