Atherogenic modification of low-density lipoproteins

Sukhorukov V.N.1 , Karagodin V.P.2, Orekhov A.N.3

1. Institute of General Pathology and Pathophysiology, Moscow, Russia
2. Plekhanov Russian University of Economics, Moscow, Russia
3. Institute of General Pathology and Pathophysiology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, PO Box #21, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20166204391      PubMed Id: 27562992
Year: 2016  Volume: 62  Issue: 4  Pages: 391-402
One of the first manifestations of atherosclerosis is accumulation of extra- and intracellular cholesterol esters in the arterial intima. Formation of foam cells is considered as a trigger in the pathogenesis of atherosclerosis. Low density lipoprotein (LDL) circulating in human blood is the source of lipids accumulated in the arterial walls. This review considered features and role in atherogenesis different modified forms of LDL: oxidized, small dense, electronegative and especially desialylated LDL. Desialylated LDL of human blood plasma is capable to induce lipid accumulation in cultured cells and it is atherogenic. LDL possesses numerous alterations of protein, carbohydrate and lipid moieties and therefore can be termed multiple-modified LDL. Multiple modification of LDL occurs in human blood plasma and represents a cascade of successive changes in the lipoprotein particle: desialylation, loss of lipids, reduction in the particle size, increase of surface electronegative charge, etc. In addition to intracellular lipid accumulation, stimulatory effects of naturally occurring multiple-modified LDL on other processes involved in the development of atherosclerotic lesions, namely cell proliferation and fibrosis, were shown.
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Keywords: atherogenicity, atherosclerosis, desialylation, intracellular lipid accumulation, low density lipoprotein, oxidation, trans-sialidase

Sukhorukov, V. N., Karagodin, V. P., Orekhov, A. N. (2016). Atherogenic modification of low-density lipoproteins. Biomeditsinskaya Khimiya, 62(4), 391-402.
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