DNA aptamers selection for breast cancer

   
Zamay G.S.1 , Belayanina I.V.2, Zamay A.S.2, Komarova M.A.2, Krat A.V.3, Eremina E.N.4, Zukov R.A.4, Sokolov A.E.5, Zamay T.N.1

1. Kirensky Institute of Physics, Krasnoyarsk, Russia; Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia
2. Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia
3. Kryzhanovsky Krasnoyarsk Regional Clinical Cancer Center, Krasnoyarsk, Russia
4. Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Kryzhanovsky Krasnoyarsk Regional Clinical Cancer Center, Krasnoyarsk, Russia
5. Kirensky Institute of Physics, Krasnoyarsk, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20166204411      UDK: 577.2      PubMed Id: 27562994
Year: 2016  Volume: 62  Issue: 4  Pages: 411-417
A method of selection of DNA aptamers to breast tumor tissue based on the use of postoperative material has been developed. Breast cancer tissues were used as the positive target; the negative targets included benign tumor tissue, adjacent healthy tissues, breast tissues from mastopathy patients, and also tissues of other types of malignant tumors. During selection a pool of DNA aptamers demonstrating selective binding to breast cancer cells and tissues and insignificant binding to breast benign tissues has been obtained. These DNA aptamers can be used for identification of protein markers, breast cancer diagnostics, and targeted delivery of anticancer drugs.
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Zamay G.S., Belayanina I.V., Zamay A.S., Komarova M.A., Krat A.V., Eremina E.N., Zukov R.A., Sokolov A.E., Zamay T.N. (2016) Biomeditsinskaya khimiya, 62(4), 411-417.
This paper is also available as the English translation:10.1134/S1990750816020128
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