Mammaglobin in peripheral blood and tumor in breast cancer patients

Bozhenko V.K.1, Kharchenko N.V.2, Vaskevich E.F.3, Kudinova E.A.1, Oorzhak A.V.1, Rozhkova N.I.4, Trotsenko I.D.2

1. Russian Scientific Center of Roentgenoradiology, Moscow, Russia
2. People Friendship University of Russia, Moscow, Russia
3. 3Clinical diagnostic centre No.1, Moscow, Russia
4. National center of Oncology of the reproductive organs, Moscow, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166204453      PubMed Id: 27563000
Year: 2016  Volume: 62  Issue: 4  Pages: 453-457
Currently, no molecular biological markers do exist for early diagnosis of breast cancer. One of the possible candidates for the marker of early breast cancer is mammaglobin (MGB1) or SCGB2A2 (secretoglobin, family 2A, member 2), characterized by the maximal expression level in early breast cancer. Using the RT-PCR method MGB1 mRNA expression was examined in 57 tumor tissue samples and 57 samples of morphologically non-malignant tissue (MNT) of breast cancer (BC) patients. Specificity and sensitivity of the MGB1 mRNA assay in peripheral blood of BC patients was evaluated by nested PCR. 169 blood samples (from 95 BC patients, 22 from patients with benign breast tumors, 28 from patients with tumors of other localizations, and 24 samples from healthy donors) have been analyzed. MGB1 expression was significantly higher in BC tissue samples compared to MNT (p=0.0019). The maximal expression level was in the samples T1 (p=0.013), stage I BC (p=0.037), GI (p=0.0019). The MGB1 expression positively correlated with expression of estrogen (p = 0,034) and progesterone (p=0.0004) receptors. Sensitivity and specificity of the MGB1 mRNA assay in peripheral blood were 60.6% and 92.3%, respectively. Expression of MGB1 was higher in BC than MNT and it decreased during BC progression. The sensitivity and specificity of the MGB1 mRNA assay may be used as an additional diagnostic method.
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Keywords: breast cancer, mRNA mammaglobin expression, mammaglobin in peripheral blood

Bozhenko, V. K., Kharchenko, N. V., Vaskevich, E. F., Kudinova, E. A., Oorzhak, A. V., Rozhkova, N. I., Trotsenko, I. D. (2016). Mammaglobin in peripheral blood and tumor in breast cancer patients. Biomeditsinskaya Khimiya, 62(4), 453-457.
This paper is also available as the English translation: 10.1134/S1990750816010030
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