1. Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, Kazan, Russia 2. Interregional Clinical Diagnostic Center, Kazan, Russia 3. Kazan State Medical Academy, Kazan, Russia
Correlations between biochemical and immunological markers of programmed cell death (apoptosis), and the functional state of the thyroid gland (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). Annexin V, TRAIL and TNF-a, as well as DNA-hydrolyzing antibodies were used as the main markers. Increased levels of TRAIL were found in the serum of AT patients (hyperthyroidism>hypothyroidism>euthyroidism) compared with healthy individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had the highest frequency in AT patients (97%) compared with healthy controls. Among these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with symptoms of the thyroid dysfunction.
Keywords: apoptosis, autoantibodies, antibodies to DNA, autoimmune thyroiditis
Biktagirova E.M. et al. Biochemical and immunological markers of autoimmune thyroiditis // Biomeditsinskaya khimiya. - 2016. - V. 62. -N 4. - P. 458-465.
Biktagirova E.M. et al., "Biochemical and immunological markers of autoimmune thyroiditis." Biomeditsinskaya khimiya 62.4 (2016): 458-465.
Biktagirova, E. M., Sattarova, L. I., Vagapova, G. R., Skibo, Y. V., Chuhlovina, E. N., Kravtsova, O. A., Abramova, Z. I. (2016). Biochemical and immunological markers of autoimmune thyroiditis. Biomeditsinskaya khimiya, 62(4), 458-465.