Adenocarcinoma and squamous cell carcinoma are the most common types of esophageal cancer with a constant tendency to increase the incidence of growth on the background of the high mortality, which makes particularly the development of new biomarkers that complement and improve the early diagnosis of this disease. Despite the impressive number of studies in routine clinical practice is used only marker of esophageal cancer – ERBB2/HER2 status. This review summarizes data on the identified epigenetic markers of the aberrant methylation of the genome, which may be useful for early detection of esophageal cancer, prognosis estimation and / or prediction of response to treatment. The development of new high-tech genome-wide screening, such as beadarray and immunoprecipitation sequencing method used for the wideband genotyping, but for the analysis of transcriptome and metilom, provides a comprehensive picture of genetic and epigenetic changes during tumorigenesis. Note the need to verify the most biomarkers on large representative samples for the development of valid diagnostic panels, suitable for large-scale screening of risk groups.
Download PDF:
Keywords: adenocarcinoma and squamous cell carcinoma of the esophagus, DNA methylation, biomarkers
Citation:
Kit O.I., Vodolazhskiy D.I., Kolesnikov E.N., Timoshkina N.N. (2016) Epigenetic markers of esophageal cancer: DNA methylation. Biomeditsinskaya Khimiya, 62(5), 520-526.
Kit O.I. et al. Epigenetic markers of esophageal cancer: DNA methylation // Biomeditsinskaya Khimiya. - 2016. - V. 62. -N 5. - P. 520-526.
Kit O.I. et al., "Epigenetic markers of esophageal cancer: DNA methylation." Biomeditsinskaya Khimiya 62.5 (2016): 520-526.
Kit, O. I., Vodolazhskiy, D. I., Kolesnikov, E. N., Timoshkina, N. N. (2016). Epigenetic markers of esophageal cancer: DNA methylation. Biomeditsinskaya Khimiya, 62(5), 520-526.
Statistika zlokachestvennykh novoobrazovanij v Rossii i stranakh SNG v 2012 g. (2014) pod red. Davydova M.I., Akselya E.M. M., Izdatel'skaya gruppa RONTS, 226s. Scholar google search
Vakil N., van Zanten S.V., Kahrilas P., Dent J., Jones R. (2006) Am. J. Gastroenterol., 101, 1900-1920. CrossRef Scholar google search
Dulak A.M., Schumacher S.E., van Lieshout J., Imamura Y., Fox C., Shim B., Ramos A.H., Saksena G., Baca S.C., Baselga J. et al. (2012) Cancer Res., 72(17), 4383-4393. CrossRef Scholar google search
Shah A.K., Saunders N.A., Barbour A.P., Hill M.M. (2013) Cancer Epidemiol. Biomarkers, 22(7), 1185-1209. CrossRef Scholar google search
Murphy A., Kelly R.J. (2015) Gastroenterol. Res. Pract., 896560. Scholar google search
Shi X.Y., Bhagwandeen B., Leong A.S. (2008) Appl. Immunohistochem. Mol. Morphol., 16, 447-452. CrossRef Scholar google search
Adams L., Roth M.J., Abnet C.C., Dawsey S.P., Woodson K. (2008) Cancer Prev. Res. (Phila), 1(5), 357-361. CrossRef Scholar google search
Eads C.A., Lord R., Kurumboor S.K., Wickramasinghe K., Skinner M.L., Long T.I., Peters J.H., DeMeester T.R., Danenberg K.D., Danenberg P.V., Laird P.W., Skinner K.A. (2000) Cancer Res., 60, 5021-5026. Scholar google search
Kawakami K., Brabender J., Lord R.V., Groshen S., Greenwald B.D., Krasna M.J., Yin J., Fleisher A.S., Abraham J.M., Beer D.G. et al. (2009) J. Natl. Cancer Inst., 92, 1805-1811. CrossRef Scholar google search
Grimm M., Lazariotou M., Kircher S., Stuermer L., Reiber C., Höfelmayr A., Gattenlöhner S., Otto C., Germer C.T., von Rahden B.H. (2010) J. Transl. Med., 8, 99. CrossRef Scholar google search
Iwagami S., Baba Y., Watanabe M., Shigaki H., Miyake K., Ishimoto T., Iwatsuki M., Sakamaki K., Ohashi Y., Baba H. (2013) Ann. Surgery, 257(3), 449-455. CrossRef Scholar google search
Baba Y., Watanabe M., Murata A., Shigaki H., Miyake K., Ishimoto T., Iwatsuki M., Iwagami S., Yoshida N., Oki E., Sakamaki K., Nakao M., Baba H. (2014) Clin. Cancer Res., 20(5), 1114-1124. CrossRef Scholar google search
Zhu J., Ling Y., Xu Y., Lu M.Z., Liu Y.P., Zhang C.S. (2015) Int. J. Clin. Exp. Pathol., 8(11), 14392-13400. Scholar google search
Kaz A.M., Wong C.J., Luo Y., Virgin J.B., Washington M.K., Willis J.E., Leidner R.S., Chak A., Grady W.M. (2011) Epigenetics, 6, 1403-1412. CrossRef Scholar google search
Agarwal R., Jin Z., Yang J., Mori Y., Song J.H., Kumar S., Sato M., Cheng Y., Abraham J.M., Verma A., Meltzer S.J. (2012) Endocr. Relat. Cancer., 19(1), L5–L9. CrossRef Scholar google search
Alvarez H., Opalinska J., Zhou L., Sohal D., Fazzari M.J., Yu Y., Montagna C., Montgomery E.A., Canto M., Dunbar K.B. et al. (2011) PLoS Genet., 7. CrossRef Scholar google search
Wu W., Bhagat T.D., Yang X., Song J.H., Cheng Y., Agarwal R., Abraham J.M., Ibrahim S., Bartenstein M., Hussain Z., Suzuki M., Yu Y., Chen W., Eng C., Greally J., Verma A., Meltzer S.J. (2013) Gastroenterology, 144(5), 956-966. Scholar google search
Krause L., Nones K., Loffler K.A., Nancarrow D., Oey H., Tang Y.H., Wayte N.J., Patch A.M., Patel K., Brosda S. et al. (2016) Carcinogenesis, bgw018v2-bgw018. Scholar google search
Devriese L.A., Voest E.E., Beijnen J.H., Schellens J.H. (2011) Cancer Treat. Rev., 37, 579-589. CrossRef Scholar google search
Hoffmann A.C., Vallbohmer D., Prenzel K,. Metzger R., Heitmann M., Neiss S., Ling F., Hölscher A.H., Schneider P.M., Brabender J. (2009) J. Cancer Res. Clin. Oncol., 135, 1231-1237. Scholar google search
Almhanna K., Meredith K.L., Hoffe S.E., Shridhar R., Coppola D. (2013) Cancer Control., 20(2), 111-116. Scholar google search
Guo M., Ren J., House M.G., Qi Y., Brock M.V., Herman J.G. (2006) Clin. Cancer Res., 12, 4515-4522. CrossRef Scholar google search
Kuester D., El-Rifai W., Peng D., Ruemmele P., Kroeckel I., Peters B., Moskaluk C.A., Stolte M., Mönkemüller K., Meyer F., Schulz H.U., Hartmann A., Roessner A., Schneider-Stock R. (2009) Cancer Lett., 275, 117-126. CrossRef Scholar google search
Anupam K., Tusharkant C., Gupta S.D., Ranju R. (2006) World. J. Gastroenterol., 12, 6041-6045. CrossRef Scholar google search
Tischoff I., Hengge U.R., Vieth M., Ell C., Stolte M., Weber A., Schmidt W.E., Tannapfel A. (2007) Gut, 56, 1047-1053. CrossRef Scholar google search
Zhang M., Linghu E., Zhan Q., He T., Cao B., Brock M.V., Herman J.G., Xiang R., Guo M. (2016) Oncotarget., DOI: 10.18632/oncotarget.7647. CrossRef Scholar google search
