Melaxen administration to rats with brain ischemia/reperfusion was accompanied by a decrease of the lactate level (an organ ischemia marker), biochemiluminescence parameters characterizing the intensity of free radical processes and total antioxidant activity, the content of lipid peroxidation products, activity of superoxide dismutase and catalase, as compared with the values determined in rats with induced brain ischemia/reperfusion. Activity of aconitate hydratase, a sensitive target of free radicals action, and the citrate level in the brain and blood serum of melaxen-treated animals changed towards control values of intact animals. It is assumed that the effect of melaxen is associated with implementation of the antioxidant and protective properties of melatonin, the melaxen constituent, under conditions of post-ischemic reperfusion injury, accompanied by oxidative stress development.
Popova T.N. et al. The effect of melaxen administration on the tissue oxidative status in rats with brain ischemia/reperfusion // Biomeditsinskaya khimiya. - 2016. - V. 62. -N 5. - P. 561-565.
Popova T.N. et al., "The effect of melaxen administration on the tissue oxidative status in rats with brain ischemia/reperfusion." Biomeditsinskaya khimiya 62.5 (2016): 561-565.
Popova, T. N., Safonova, O. A., Stolyarova, A. O. (2016). The effect of melaxen administration on the tissue oxidative status in rats with brain ischemia/reperfusion. Biomeditsinskaya khimiya, 62(5), 561-565.
Bilenko M.V. (1989) Ishemicheskie i reperfuzionnye povrezhdeniya organov, Meditsina, M., 368 s. Scholar google search
Reiter R.J., Tan D.X., Terron M.P., Flores L.J., Czarnocki Z. (2007) Acta Biochimica Polonica, 54 (1), 1-9. Scholar google search
Tan D.X., Manchester L.C., Burkhardt S., Sainz R.M., Mayo J.C., Kohen R., Shohami E., Huo Y.X., Hardeland R., Reiter R.J. (2001) FASEB J., 15, 2294-2296. Scholar google search
Sanchez-Barcelo E.J., Martinez-Campa C.M., Mediavilla M.D., Gonzalez A., Alonso-Gonzalez C., Cos S. (2007) Recent patents on endocrine, metabolic and immune drug discovery, №1, 142-151. Scholar google search