Caspase activity in peripheral blood mononuclear cells (PBMC) of patients with depression and anxiety of different severity

   
Yakovlev A.A.1 , Druzhkova T.A.2, Grishkina M.N.2, Guekht A.B.3, Gulyaeva N.V.1

1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia; Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russia
2. Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russia
3. Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russia; Russian National Research Medical University, Moscow, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166205588      UDK: 577.151      PubMed Id: 27797336
Year: 2016  Volume: 62  Issue: 5  Pages: 588-592
Though borderline psychiatric disorders (BPD) are quite common diseases, their pathogenesis remains obscure. Data from several groups and our previous results suggest that the pathological changes are typical not only for brain cells, but also for cells of the immune system. One of the evident illustrations of immune and nervous systems relationship in pathogenesis of mental diseases is the death of PBMC occurring in patients with depression. We have shown previously that activities of the caspases increase in some types of BPD. In this study, we have investigated caspase activities in PBMC of patients with BPD of different severity. It has been found that in severe depressive disorder activities of caspases were reduced either as compared to healthy controls or to patients with depression lesser severity. In contrast, in patients with severe anxiety activities of caspases were higher than in both control and patients with less severe forms of anxiety disorders. Thus, the study of caspase activity in PBMC makes it possible to differentiate between severe and mild forms of BPD.
Download PDF:
Reference:

Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Guekht A.B., Gulyaeva N.V. (2016) Biomeditsinskaya khimiya, 62(5), 588-592.
This paper is also available as the English translation:10.1134/S1990750817010103
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)