The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis

Esmedlyaeva D.S.1 , Alexeyeva N.P.2, Sapozhnikova N.V.1, Dyakova M.E.1, Perova T.L.1, Kiryukhina L.D.1, Zhuravlev V.Y.1

1. Institute of Phthisiopulmonology, Saint-Petersburg, Russia
2. Institute of Phthisiopulmonology, Saint-Petersburg, Russia; Valdman Institute of Pharmacology, Saint-Petersburg, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166205593      PubMed Id: 27797337
Year: 2016  Volume: 62  Issue: 5  Pages: 593-598
The aim of this study was to examine the relationship between serum levels of parameters of the system metalloproteinase (MMP)/inhibitors with severity of infiltrative pulmonary tuberculosis (ITL), changes in examined parameters during the intensive phase treatment (IPT), as well as possibility of their use for prediction of IPT effectiveness, along with acute-phase proteins (AFP). The study included ITL patients which were subdivided into two groups (I and II) with different rates of reparative changes. It was shown that: 1) ITL is characterized by impairements in the system MMP/inhibitors: the levels of MMP-1, -9 increased, MMP-3, -8, TIMP-1 remained at the reference values and a 2-macroglobulin was low. 2) Changes of the parameters of the system MMP/inhibitors were associated with markers of severity and activity of the process: MMP-1, with the presence of destruction and sensitivity of the pathogen (Mycobacterium tuberculosis; MBT) to anti-TB drugs, MMP-9, with the volume of destruction, MMP-8 – with activity of tuberculosis. 3) TIMP-1 and MMP-9 concentrations decreased during treatment in groups with different rates of reparative process, whereas proMMP-1, MMP-3,-8 remained unchanged. 4) Before and after IPT, the level of TIMP-1 was higher in the group of patients with slower rate of reparative processes. 5) After IPT the imbalance in the system MMP/inhibitor preserved thus suggesting continuation of the reparative process. 6) Use of combination of MMP and AFR is more informative in predicting efficacy of IPT.
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Keywords: tuberculosis, matrix metalloproteinases, matrix metalloproteinase inhibitors, acute phase proteins, reparation

Esmedlyaeva, D. S., Alexeyeva, N. P., Sapozhnikova, N. V., Dyakova, M. E., Perova, T. L., Kiryukhina, L. D., Zhuravlev, V. Y. (2016). The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis. Biomeditsinskaya Khimiya, 62(5), 593-598.
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