Comparative proteome analysis of blood plasma of patients with early-stage chronic cerebral ischemia

   
Kisrieva Y.S.1 , Petushkova N.A.1, Samenkova N.F.1, Kuznetsova G.P.1, Larina O.V.1, Zavialova M.G.1, Teryaeva N.B.2, Belyaev A.Y.2, Karuzina I.I.1

1. Institute of Biomedical Chemistry, Moscow, Russia
2. Burdenko Institute of Neurosurgery, Moscow, Russia
Section: Short Communication
DOI: 10.18097/PBMC20166205599      PubMed Id: 27797338
Year: 2016  Volume: 62  Issue: 5  Pages: 599-602
In the present study, we explored the technology of liquid chromatography-mass spectrometry (HPLC-MS/MS) for the proteome analysis of blood plasma of patients with early chronic cerebral ischemia. Analysis of mass-spectrometer data carried out in automatic mode using the software Progenesis LS-MS. As a result of this study identified 43 proteins. The differences identified in the study group compared with the control in 7 proteins. It was found that in the early stages of chronic cerebral ischemia proteome changes in blood plasma affect proteins related to the immune system, the system for the maintenance of hemostasis and lipid metabolism.
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Keywords: cerebral ischemia, blood plasma proteome, Liquid Chromatography and Mass Spectrometry, Orbitrap
Citation:

Kisrieva, Y. S., Petushkova, N. A., Samenkova, N. F., Kuznetsova, G. P., Larina, O. V., Zavialova, M. G., Teryaeva, N. B., Belyaev, A. Y., Karuzina, I. I. (2016). Comparative proteome analysis of blood plasma of patients with early-stage chronic cerebral ischemia. Biomeditsinskaya khimiya, 62(5), 599-602.
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