Trophic factors deprivation induces long-term protection of neurons against excitotoxic damage

Yakovlev A.A.1 , Lyzhin A.A.2, Aleksandrova O.P.2, Khaspekov L.G.2, Gulyaeva N.V.1

1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia; Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia
2. Brain Research Center at Research Center of Neurology, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20166206656      UDK: 577.151      PubMed Id: 28026809
Year: 2016  Volume: 62  Issue: 6  Pages: 656-663
One of the strategies to induce tolerance of neurons to toxic injury is preconditioning. Preconditioning is caused by a weak damage of cells, which become more resistant to subsequent, more severe damage. We found that preconditioning by deprivation of trophic factors, or deprivation of trophic factor and glucose effectively protects neurons against subsequent toxic effects of glutamate. Deprivation of trophic factors plays a decisive role in the development of resistance, regardless of whether it has been combined with glucose deprivation or not. Neuronal protection is achieved when the deprivation lasts from 30 min to two hours and is kept for a period of from one to five days. Preconditioning is accompanied neuronal secretion of cathepsin B occurs. We suggest that this phenomenon is associated with a more general process of exocytosis of lysosomes triggered by deprivation of trophic factors.
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Yakovlev A.A., Lyzhin A.A., Aleksandrova O.P., Khaspekov L.G., Gulyaeva N.V. (2016) Biomeditsinskaya khimiya, 62(6), 656-663.
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