Investigation of efficacy of phospholipovit for correction of the hepatic encephalopathy

Kudinov V.A.1 , Ipatova O.M.1, Fyodorov I.G.2, Totolyan G.G.2, Merzlikina N.N.3, Kovalyov O.B.3, Torkhovskaya T.I.1, Uchaikin V.F.3, Starovoitova I.E.4, Milyutin D.V.4, Nikonova S.M.5

1. Institute of Biomedical Chemistry, Moscow, Russia
2. City Clinical Hospital №12 / 115516, Moscow, Russia
3. Russian State Medical University, the Scientific Center of Children Health, Moscow, Russia
4. City Drug Hospital, St. Petersburg, Russia
5. North-West Research center of Hygiene and Public Health, St. Petersburg, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20166206704      PubMed Id: 28026815
Year: 2016  Volume: 62  Issue: 6  Pages: 704-707
This paper presents the results of clinical studies on the efficacy and safety of the drug Phospholipovit in different groups of patients, in particular with hepatic encephalopathy and with a high risk of its development (chronic alcohol intoxication). Efficacy of treatmernt was evaluated by the LNT test (link numbers test), and standard liver plasma markers (ALT, AST, GGT, AP). The LNT test in patients with encephalopathy showed better improvement after 5 days course of Phos-pholipovit than after standard therapy. In both clinical trials liver enzyme activities, assayed in pa-tients declined more rapidly in the group of patients treated with Phospholipovit, as compared in patients received standard therapy alone. The highest clinical effect of the drug on the liver function tests was observed at a daily dose of 6.4 g of phospholipids (infusional 2 times a day) for 5-10 days. At the end of treatment a two-fold decrease in the activity of AST was observed in patients receiv-ing Phospholipovit compared to the control. This results of clinical results can be regarded as a manifestation of the expressed membrane repairing action of essential phospholipids, reinforced by their introduction into the body in the form of nanoparticles.
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Keywords: essential phospholipids, phospholipid nanoparticles, hepatic encephalopathy, reparation of membranes

Kudinov, V. A., Ipatova, O. M., Fyodorov, I. G., Totolyan, G. G., Merzlikina, N. N., Kovalyov, O. B., Torkhovskaya, T. I., Uchaikin, V. F., Starovoitova, I. E., Milyutin, D. V., Nikonova, S. M. (2016). Investigation of efficacy of phospholipovit for correction of the hepatic encephalopathy. Biomeditsinskaya Khimiya, 62(6), 704-707.
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