Morphofunctional changes of dendritic cells induced by sulfated polysaccharides of brown algae

   
Makarenkova I.D.1 , Akhmatova N.K.2, Ermakova S.P.3, Besednova N.N.1

1. Somov Scientific Research Institute of Epidemiology and Microbiology, Vladivostok, Russia
2. Mechnikov Scientific Research Institute of Vaccines and Sera, Moscow, Russia
3. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RUS Vladivostok, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20176301039      PubMed Id: 28251950
Year: 2017  Volume: 63  Issue: 1  Pages: 39-46
The effects of various sulfated polysaccharides of brown algae Fucus evanescens, Saccharina cichorioides and Saccharina japonica on the morphofunctional changes of dendritic cells have been investigated using flow cytometry and phase-contrast microscopy. The dendritic cells are characterized by larger sizes, vacuolated cytoplasm, eccentrically located nucleus, and also by the presence of numerous cytoplasmic pseudopodia of various shapes. They express surface markers, indicating their maturation (CD83, CD11c, HLA-DR, CD86). Increased production of immunoregulatory (IL-12) and proinflammatory TNF-a, IL-6) cytokines (by dendritic cells polarizes the development of the Th-1 type immune response.
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Keywords: dendritic cells, sulfated polysaccharides, morphology, fucoidan, cytokines
Citation:

Makarenkova, I. D., Akhmatova, N. K., Ermakova, S. P., Besednova, N. N. (2017). Morphofunctional changes of dendritic cells induced by sulfated polysaccharides of brown algae. Biomeditsinskaya khimiya, 63(1), 39-46.
This paper is also available as the English translation: 10.1134/S1990750817030076
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