Heterodimeric D1-D2 dopamine receptors: a review

Vekshina N.L.1 , Anokhin P.K.1, Veretinskaya A.G.1, Shamakina I.Yu.1

1. V.P. Serbsky Federal Medical Research Center on Psychiatry and Narcology, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20176301005      PubMed Id: 28251946
Year: 2017  Volume: 63  Issue: 1  Pages: 5-12
This review summarizes modern data on the structure and functions ofheteromersformed by D1 and D2 dopamine receptors focusing on their role in the mechanisms of drug dependence. This article discusses potential functional significance of heterodimeric D1-D2 dopamine receptorsdue to their localization in the brain as well as unique pharmacological propertiesversus constituent monomers. It is shown that heteromerization results in dramatic changes in activated signaling pathways compare to the corresponding monomers. These studies update our current knowledge of ligand-receptor interactions and provide better understanding of dopamine receptors pharmacology. Furthermore elucidation of significance of heterodimeric D1-D2 dopamine receptors as drug targets is important for the development of new effective drug addiction treatment.
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Keywords: mesolimbic system, dopamine receptors, heteromers, psychoactive substances, drug dependence

Vekshina, N. L., Anokhin, P. K., Veretinskaya, A. G., Shamakina, I. Yu. (2017). Heterodimeric D1-D2 dopamine receptors: a review. Biomeditsinskaya khimiya, 63(1), 5-12.
This paper is also available as the English translation: 10.1134/S199075081702010X
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