Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy

   
Popovtseva A.V.1 , Suzopov E.V.2, Korenovsky Yu.V.2

1. Federal Centre of Traumatology, Orthopedics and Endoprosthesis Replacement, Barnaul, Altai Region, Russia
2. Altai State Medical University, Barnaul, Altai Region, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20176301081      PubMed Id: 28251955
Year: 2017  Volume: 63  Issue: 1  Pages: 81-84
We evaluated the influence of hypoxic hypoxia on lactate, creatinine and urea concentrations in the amniotic fluid (AF) of rabbits on 27-28th day of pregnancy. Rabbits were randomly sudivided into two groups: experimental (n=9) and control (n=6). Rabbits of experimental groups were placed in a hypoxic chamber containing 10±2% oxygen and 90±2% nitrogen for 1 h and then were euthanized, AF was extracted from the amniotic sacs via disposable syringe. Acute hypoxic hypoxia had no effect on the AF volume, increased (1.4-fold) lactate, (1.3-fold) creatinine and (1.1-fold) urea concentrations in AF. In contrast to animals of the control group, lactate concentration in the groups with hypoxic hypoxia correlated with the creatinine (r=0.71, p<0.0001, n=35) and urea concentrations in the AF (r=0.81, p<0.0001, n=35). These results suggest that acute hypoxic hypoxia in late pregnancy causes changes in the biochemical composition of AF; these changes are characterized by high lactate concentrations, and the fetus and uterus can be the source of increased lactate level in AF.
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Keywords: lactate, amniotic fluid, hypoxia
Citation:

Popovtseva, A. V., Suzopov, E. V., Korenovsky, Yu. V. (2017). Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy. Biomeditsinskaya khimiya, 63(1), 81-84.
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