Pharmacometabonomics – the novel way to personalized drug therapy

Maslov D.L.1 , Balashova E.E.1, Lokhov P.G.1, Archakov A.I.1

1. Institute of Biomedical Chemistry, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20176302115      PubMed Id: 28414282
Year: 2017  Volume: 63  Issue: 2  Pages: 115-123
The review is devoted to pharmacometabonomics - a new branch of science focused on personalization of drug therapy through the comprehensive analysis of metabolites of patient's biological fluids. It considers the history of pharmacometabonomic, positioning to other “-omic” sciences, and system approach, realized by this science, in determination of individual therapeutic dose of the drugs and also a technical implementation of pharmacometabonomic based on direct mass spectrometry of blood plasma metabolites. Special attention is paid to a comparative analysis of pharmacometabonomics and other main approaches to personalized therapy in the clinic, such as pharmacogenetics and therapeutic drug monitoring. Finally, prospects of pharmacometabonomics applications in clinical practice were also discussed.
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Keywords: pharmacometabonomics, metabolomics, metabonomics, pharmacogenomics, mass spectrometry, personalized medicine, therapeutic drug monitoring

Maslov, D. L., Balashova, E. E., Lokhov, P. G., Archakov, A. I. (2017). Pharmacometabonomics – the novel way to personalized drug therapy. Biomeditsinskaya khimiya, 63(2), 115-123.
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