The conditions of Moscow 2010 summer heat wave were simulated in an accommodation module. Six healthy men aged from 22 to 46 years stayed in the module for 30 days. Measurements of gene expression in peripheral blood leukocytes before, during and 3 day after simulated heat wave were performed using qRT-PCR. We observed a shift in the expression level of certain genes after heat exposure for a long time, and rapid return to the initial level, when volunteers leaved the accommodation module. Eight genes were chosen to form the “heat expression signature”. EGR2, EGR3 were upregulated in all six volunteers, EGR1, SIRT1, CYP51A1, MAPK9, BAG5, MNDA were upregulated in 5 volunteers.
Feoktistova E.S. et al. Analysis of gene expression pattern in peripheral blood leukocytes during experimental heat wave // Biomeditsinskaya Khimiya. - 2017. - V. 63. -N 2. - P. 139-146.
Feoktistova E.S. et al., "Analysis of gene expression pattern in peripheral blood leukocytes during experimental heat wave." Biomeditsinskaya Khimiya 63.2 (2017): 139-146.
Feoktistova, E. S., Skamrov, A. V., Goryunova, L. E., Khaspekov, G. L., Osyaeva, M. K., Rodnenkov, O. V., Beabealashvilli, R. Sh. (2017). Analysis of gene expression pattern in peripheral blood leukocytes during experimental heat wave. Biomeditsinskaya Khimiya, 63(2), 139-146.
References
Nauchno-koordinatsionnyy komitet po podgotovke “Otsenochnogo doklada ob izmeneniyakh klimata i ikh posledstviyakh na territorii Rossiyskoy Federatsii” (2008) Otsenochnyy doklad ob izmeneniyakh klimata i ikh posledstviyakh na territorii Rossiyskoy Federatsii. ISBN 978-5-904206-01-7. Scholar google search
Nauchno-koordinatsionnyy komitet po podgotovke “Vtorogo otsenochnogo doklada Rosgidrometa ob izmeneniyakh klimata i ikh posledstviyakh na territorii Rossiyskoy Federatsii” (2014) Vtoroy otsenochnyy doklad Rosgidrometa ob izmeneniyakh klimata i ikh posledstviyakh na territorii Rossiyskoy Federatsii. ISBN 978-5-904206-13-0. Scholar google search
Rosgidromet (2015) Doklad ob osobennostyakh klimata na territorii Rossiyskoy Federatsii za 2014 god. 1, 1-107. ISBN 978-5-906099-58-7. Scholar google search
