Analysis of gene expression pattern in peripheral blood leukocytes during experimental heat wave

   
Feoktistova E.S.1, Skamrov A.V.1 , Goryunova L.E.1, Khaspekov G.L.1, Osyaeva M.K.1, Rodnenkov O.V.1, Beabealashvilli R.Sh.1

1. Cardiology Scientific and Production Complex, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20176302139      PubMed Id: 28414285
Year: 2017  Volume: 63  Issue: 2  Pages: 139-146
The conditions of Moscow 2010 summer heat wave were simulated in an accommodation module. Six healthy men aged from 22 to 46 years stayed in the module for 30 days. Measurements of gene expression in peripheral blood leukocytes before, during and 3 day after simulated heat wave were performed using qRT-PCR. We observed a shift in the expression level of certain genes after heat exposure for a long time, and rapid return to the initial level, when volunteers leaved the accommodation module. Eight genes were chosen to form the “heat expression signature”. EGR2, EGR3 were upregulated in all six volunteers, EGR1, SIRT1, CYP51A1, MAPK9, BAG5, MNDA were upregulated in 5 volunteers.
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Feoktistova E.S., Skamrov A.V., Goryunova L.E., Khaspekov G.L., Osyaeva M.K., Rodnenkov O.V., Beabealashvilli R.Sh. (2017) Biomeditsinskaya khimiya, 63(2), 139-146.
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