To date lung adenocarcinoma (LAC) is the most common type of lung cancer. Numerous studies on LAC biology resulted in identification of crucial mutations in protooncogenes and activating neoplastic transformation pathways. Therapeutic approaches that significantly increase the survival rate of patients with LAC of different etiology have been developed and introduced into clinical practice. However, the main problem in the treatment of LAC is early diagnosis, taking into account both factors and mechanisms responsible in tumor initiation and progression. Identification of a wide biomarker repertoire with high specificity and reliability of detection appears to be a solution to this problem. In this context, proteins with differential expression in normal and pathological condition, suitable for detection in biological fluids are the most promising biomarkers. In this review we have analyzed literature data on studies aimed at search of LAC biomarkers. The major attention has been paid to protein biomarkers as the most promising and convenient subject of clinical diagnosis. The review also summarizes existing knowledge on posttranslational modifications, splice variants, isoforms, as well as model systems and transcriptome changes in LAC.
Novikova S.E. et al. Omics technologies in diagnostics of lung adenocarcinoma // Biomeditsinskaya Khimiya. - 2017. - V. 63. -N 3. - P. 181-210.
Novikova S.E. et al., "Omics technologies in diagnostics of lung adenocarcinoma." Biomeditsinskaya Khimiya 63.3 (2017): 181-210.
Novikova, S. E., Kurbatov, L. K., Zavialova, M. G., Zgoda, V. G., Archakov, A. I. (2017). Omics technologies in diagnostics of lung adenocarcinoma. Biomeditsinskaya Khimiya, 63(3), 181-210.
Travis W.D., Brambilla E., Nicholson A.G., Yatabe Y., Austin J.H., Beasley M.B., Chirieac L.R., Dacic S., Duhig E., Flieder D.B. et al. (2015) J. Thorac. Oncol., 10, 1243-1260. CrossRef Scholar google search
Govindan R., Page N., Morgensztern D., Read W., Tierney R., Vlahiotis A., Spitznagel E.L., Piccirillo J. (2006) J. Clin. Oncol., 24, 4539-4544. CrossRef Scholar google search
Koivunen J.P., Mermel C., Zejnullahu K., Murphy C., Lifshits E., Holmes A.J., Choi H.G., Kim J., Chiang D., Thomas R. et al. (2008) Clin. Cancer Res., 14, 4275-4283. CrossRef Scholar google search
Cardarella S., Ogino A., Nishino M., Butaney M., Shen J., Lydon C., Yeap B.Y., Sholl L.M., Johnson B.E., Jänne P.A. (2013) Clin. Cancer Res., 19, 4532-4540. CrossRef Scholar google search
Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., Harris P.L., Haserlat S.M., Supko J.G., Haluska F.G., Louis D.N., Christiani D.C., Settleman J., Haber D.A. (2004) N. Engl. J. Med., 350, 2129-2139. CrossRef Scholar google search
Buttitta F., Barassi F., Fresu G., Felicioni L., Chella A., Paolizzi D., Lattanzio G., Salvatore S., Camplese P.P., Rosini S., Iarussi T., Mucilli F., Sacco R., Mezzetti A., Marchetti A. (2006) Int. J. Cancer., 119, 2586-2591. CrossRef Scholar google search
Arcila M.E., Drilon A., Sylvester B.E., Lovly C.M., Borsu L., Reva B., Kris M.G., Solit D.B., Ladanyi M. (2015) Clin. Cancer Res., 21, 1935-1943. CrossRef Scholar google search
Ju Y.S., Lee W.C., Shin J.Y., Lee S., Bleazard T., Won J.K., Kim Y.T., Kim J.I., Kang J.H., Seo J.S. (2012) Genome Res., 22, 436-445. CrossRef Scholar google search
Sun Y., Ren Y., Fang Z., Li C., Fang R., Gao B., Han X., Tian W., Pao W., Chen H., Ji H. (2010) J. Clin. Oncol., 28, 4616-4620. CrossRef Scholar google search
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y. et al. (2007) Cell., 131, 1190-1203. CrossRef Scholar google search
Virmani A.K., Rathi A., Sathyanarayana U.G., Padar A., Huang C.X., Cunnigham H.T., Farinas A.J., Milchgrub S., Euhus D.M., Gilcrease M., Herman J., Minna J.D., Gazdar A.F. (2001) Clin. Cancer Res., 7, 1998-2004. Scholar google search
Zöchbauer-Müller S., Fong K.M., Virmani A.K., Geradts J., Gazdar A.F., Minna J.D. (2001) Cancer Res., 61, 249-255. Scholar google search
Søes S., Daugaard I.L., Sørensen B.S., Carus A., Mattheisen M., Alsner J., Overgaard J., Hager H., Hansen L.L., Kristensen L.S. (2014) Oncoscience, 1, 367-374. CrossRef Scholar google search
Schliekelman M.J., Taguchi A., Zhu J., Dai X., Rodriguez J., Celiktas M., Zhang Q., Chin A., Wong C.H., Wang H. et al. (2015) Cancer Res., 75, 1789-1800. CrossRef Scholar google search
Kim S.C., Jung Y., Park J., Cho S., Seo C., Kim J., Kim P., Park J., Seo J., Kim J. et al. (2013) PLoS One., 8, e55596. CrossRef Scholar google search
Han S.S., Kim W.J., Hong Y., Hong S.H., Lee S.J., Ryu D.R., Lee W., Cho Y.H., Lee S., Ryu Y.J. et al. (2014) Lung Cancer., 84, 229-235. CrossRef Scholar google search
Toh C.K., Gao F., Lim W.T., Leong S.S., Fong K.W., Yap S.P., Hsu A.A., Eng P., Koong H.N., Thirugnanam A., Tan E.H. (2006) J. Clin. Oncol., 24, 2245-2251. CrossRef Scholar google search
Molina R., Filella X., Augé J.M., Fuentes R., Bover I., Rifa J., Moreno V., Canals E., Viñolas N., Marquez A., Barreiro E., Borras J., Viladiu P. (2003) Tumour Biol., 24, 209-218. Scholar google search
Chen G., Gharib T.G., Huang C.C., Thomas D.G., Shedden K.A., Taylor J.M., Kardia S.L., Misek D.E., Giordano T.J., Iannettoni M.D., Orringer M.B., Hanash S.M., Beer D.G. (2002) Clin. Cancer Res., 8, 2298-2305. Scholar google search
Kikuchi T., Hassanein M., Amann J.M., Liu Q., Slebos R.J., Rahman S.M., Kaufman J.M., Zhang X., Hoeksema M.D., Harris B.K. et al. (2012) Mol. Cell. Proteomics, 11, 916-932. CrossRef Scholar google search
Hsu C.H., Hsu C.W., Hsueh C., Wang C.L., Wu Y.C., Wu C.C., Liu C.C., Yu J.S., Chang Y.S., Yu C.J. (2016) Mol. Cell. Proteomics, 15, 2396-2410. CrossRef Scholar google search
Okayama A., Miyagi Y., Oshita F., Nishi M., Nakamura Y., Nagashima Y., Akimoto K., Ryo A., Hirano H. (2014) J. Proteome Res., 13, 4686-4694. CrossRef Scholar google search
Li Y., Wang X., Ao M., Gabrielson E., Askin F., Zhang H., Li Q.K. (2013) Clin. Proteomics, 10, 15. CrossRef Scholar google search
Zhou X., Xue L., Hao L., Liu S., Zhou F., Xiong H., Qi X., Lin D., Shao S. (2013) Biomed. Pharmacother., 67, 621-627. CrossRef Scholar google search
Taguchi A., Delgado O., Celiktaє M., Katayama H., Wang H., Gazdar A.F., Hanash S.M. (2014) Proteomics, 14, 2750-2759. CrossRef Scholar google search
Wu H.Y., Goan Y.G., Chang Y.H., Yang Y.F., Chang H.J., Cheng P.N., Wu C.C., Zgoda V.G., Chen Y.J., Liao P.C. (2015) J. Proteome Res., 14, 3039-3050. Scholar google search
Ruhaak L.R., Nguyen U.T., Stroble C., Taylor S.L., Taguchi A., Hanash S.M., Lebrilla C.B., Kim K., Miyamoto S. (2013) Proteomics Clin. Appl., 7, 664-676. Scholar google search
Zhang X., Belkina N., Jacob H.K., Maity T., Biswas R., Venugopalan A., Shaw P.G., Kim M.S., Chaerkady R., Pandey A., Guha U. (2015) Proteomics, 15, 340-355. CrossRef Scholar google search
Wu Q., Cheng Z., Zhu J., Xu W., Peng X., Chen C., Li W., Wang F., Cao L., Yi X., Wu Z., Li J., Fan P. (2015) Sci. Rep., 5, 9520. CrossRef Scholar google search
Gu H., Ren J.M., Jia X., Levy T., Rikova K., Yang V., Lee K.A., Stokes M.P., Silva J.C. (2016) Mol. Cell. Proteomics, 15, 692-702. CrossRef Scholar google search
Sun H., Xing X., Li J., Zhou F., Chen Y., He Y., Li W., Wei G., Chang X., Jia J., Li Y., Xie L. (2013) BMC Genomics., 14, S5. CrossRef Scholar google search
Zhang Q., Taguchi A., Schliekelman M., Wong C.H., Chin A., Kuick R., Misek D.E., Hanash S. (2011) Int. J. Proteomics, 2011, 145010. CrossRef Scholar google search
Taguchi A., Politi K., Pitteri S.J., Lockwood W.W., Faça V.M., Kelly-Spratt K., Wong C.H., Zhang Q., Chin A., Park K.S. et al. (2011) Cancer Cell., 20, 289-299. CrossRef Scholar google search
Nagaraj N., Wisniewski J.R., Geiger T., Cox J., Kircher M., Kelso J., Pääbo S., Mann M. (2011) Mol. Syst. Biol., 7, 548. CrossRef Scholar google search
Bantscheff M., Lemeer S., Savitski M.M., Kuster B. (2012) Anal. Bioanal. Chem., 404, 939-965. CrossRef Scholar google search
Hibi K., Westra W.H., Borges M., Goodman S., Sidransky D., Jen J. (1999) Am. J. Pathol., 155, 711-715. CrossRef Scholar google search
Brichory F., Beer D., Le Naour F., Giordano T., Hanash S. (2001) Cancer Res., 61, 7908-7912. Scholar google search
Cabibbo A., Pagani M., Fabbri M., Rocchi M., Farmery M.R., Bulleid N.J., Sitia R. (2000) J. Biol. Chem., 275, 4827-4833. CrossRef Scholar google search
Seol S.Y., Kim C., Lim J.Y., Yoon S.O., Hong S.W., Kim J.W., Choi S.H., Cho J.Y. (2016) Cancer Res. Treat., 48, 1196-1209. CrossRef Scholar google search
Jang S.W., Liu X., Fu H., Rees H., Yepes M., Levey A., Ye K. (2009) J. Biol. Chem., 284, 24512-24525. CrossRef Scholar google search
Minamida S., Iwamura M., Kodera Y., Kawashima Y., Tabata K., Matsumoto K., Fujita T., Satoh T., Maeda T., Baba S. (2011) Anal. Bioanal. Chem., 401, 245-252. CrossRef Scholar google search
Kobayashi M., Nagashio R., Jiang S.X., Saito K., Tsuchiya B., Ryuge S., Katono K., Nakashima H., Fukuda E., Goshima N., Satoh Y., Masuda N., Saegusa M., Sato Y. (2015) Lung Cancer, 90, 342-345. CrossRef Scholar google search
Chen H., Suzuki M., Nakamura Y., Ohira M., Ando S., Iida T., Nakajima T., Nakagawara A., Kimura H. (2005) Lung Cancer, 50, 43-49. CrossRef Scholar google search
Kukulj S., Jaganjac M., Boranic M., Krizanac S., Santic Z., Poljak-Blazi M. (2010) Med. Oncol., 27, 268-277. CrossRef Scholar google search
Fritzsche F.R., Dahl E., Dankof A., Burkhardt M., Pahl S., Petersen I., Dietel M., Kristiansen G. (2007) Histol. Histopathol., 22, 703-708. Scholar google search
Xu N., Wang Y.S., Pan W.B., Xiao B., Wen Y.J., Chen X.C., Chen L.J., Deng H.X., You J., Kan B., Fu A.F., Li D., Zhao X., Wei Y.Q. (2008) Mol. Cancer Ther., 7, 1588-1597. CrossRef Scholar google search
Wang C.Y., Chen C.L., Tseng Y.L., Fang Y.T., Lin Y.S., Su W.C., Chen C.C., Chang K.C., Wang Y.C., Lin C.F. (2012) J. Biol. Chem., 287, 32512-32524. CrossRef Scholar google search
Matsuda Y., Yamamoto T., Kudo M., Kawahara K., Kawamoto M., Nakajima Y., Koizumi K., Nakazawa N., Ishiwata T., Naito Z. (2008) Int. J. Oncol., 33, 1177-1185. Scholar google search
Dauphin M., Barbe C., Lemaire S., Nawrocki-Raby B., Lagonotte E., Delepine G., Birembaut P., Gilles C., Polette M. (2013) Lung Cancer, 81, 117-122. CrossRef Scholar google search
Yousefi Z., Sarvari J., Nakamura K., Kuramitsu Y., Ghaderi A., Mojtahedi Z. (2012) Folia Histochem. Cytobiol., 50, 368-374. CrossRef Scholar google search
Maraver A., Fernandez-Marcos P.J., Herranz D., Cañamero M., Muñoz-Martin M., Gómez-López G., Mulero F., Megías D., Sanchez-Carbayo M., Shen J., Sanchez-Cespedes M., Palomero T., Ferrando A., Serrano M. (2012) Cancer Cell, 22, 222-234. Scholar google search
Hoagland L.F. 4th, Campa M.J., Gottlin E.B., Herndon J.E. 2nd, Patz E.F. Jr. (2007) Cancer, 110, 2260-2268. CrossRef Scholar google search
Arnold J.N., Saldova R., Galligan M.C., Murphy T.B., Mimura-Kimura Y., Telford J.E., Godwin A.K., Rudd P.M. (2011) J. Proteome Res., 10, 1755-1764. CrossRef Scholar google search
Ruhaak L.R., Nguyen U.T., Stroble C., Taylor S.L., Taguchi A., Hanash S.M., Lebrilla C.B., Kim K., Miyamoto S. (2013), Proteomics Clin. Appl., 7, 664-676. Scholar google search
Ruhaak L.R., Taylor S.L., Stroble C., Nguyen U.T., Parker E.A., Song T., Lebrilla C.B., Rom W.N., Pass H., Kim K., Kelly K., Miyamoto S. (2015) J Proteome Res., 14, 4538-4549. CrossRef Scholar google search
Landi M.T., Dracheva T., Rotunno M., Figueroa J.D., Liu H., Dasgupta A., Mann F.E., Fukuoka J., Hames M., Bergen A.W et al. (2008) PLoS One., 3, e1651. CrossRef Scholar google search
Lee M.J., Yaffe M.B. (2016) Cold Spring Harb. Perspect. Biol., 8, pii: a005918. Scholar google search
Ferreri A.J., Illerhaus G., Zucca E., Cavalli F.; International Extranodal Lymphoma Study Group (2010) Nat. Rev. Clin. Oncol., 7. CrossRef Scholar google search
Greenhalgh J., Bagust A., Boland A., Dwan K., Beale S., Hockenhull J., Proudlove C., Dundar Y., Richardson M., Dickson R., Mullard A., Marshall E. (2015) Health Technol. Assess., 19, 1-134. Scholar google search
Machida K., Eschrich S., Li J., Bai Y., Koomen J., Mayer B.J., Haura E.B. (2010) PLoS One., 5(10), e13470. CrossRef Scholar google search
Berndt A., Cario C.L., Silva K.A., Kennedy V.E., Harrison D.E., Paigen B., Sundberg J.P. (2011) Cancer Res., 71, 5779-5791. CrossRef Scholar google search
Chen X., Song N., Matsumoto K., Nanashima A., Nagayasu T., Hayashi T., Ying M., Endo D., Wu Z., Koji T. (2013) Int. J. Oncol., 43, 1467-1480. Scholar google search
Van Den Broeck A., Brambilla E., Moro-Sibilot D., Lantuejoul S., Brambilla C., Eymin B., Khochbin S., Gazzeri S. (2008) Clin. Cancer Res., 14, 7237-7245. CrossRef Scholar google search
Lodish H., Baltimore D., Berk A., Zipursky S.L., Matsudaira P., Darnell J. (1995) in: Molecular Cell Biology, Freeman, New York: Freeman. Scholar google search
Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D. (1994) in: Molecular Biology of the Cell, Garland, New York. Scholar google search
Choi Y.L., Takeuchi K., Soda M., Inamura K., Togashi Y., Hatano S., Enomoto M., Hamada T., Haruta H., Watanabe H. et al. (2008) Cancer Res., 68, 4971-4976. CrossRef Scholar google search
Futreal P.A., Coin L., Marshall M., Down T., Hubbard T., Wooster R., Rahman N., Stratton M.R. (2004) Nat. Rev. Cancer, 4, 177-183. CrossRef Scholar google search
Kunishima S., Matsushita T., Kojima T., Amemiya N., Choi Y.M., Hosaka N., Inoue M., Jung Y., Mamiya S., Matsumoto K. et al. (2001) J. Hum. Genet., 46, 722-729. CrossRef Scholar google search
Soda M., Choi Y.L., Enomoto M., Takada S., Yamashita Y., Ishikawa S., Fujiwara S., Watanabe H., Kurashina K., Hatanaka H. et al. (2007) Nature, 448, 561-566. CrossRef Scholar google search
Lamant L., Gascoyne R.D., Duplantier M.M., Armstrong F., Raghab A., Chhanabhai M., Rajcan-Separovic E., Raghab J., Delsol G., Espinos E. (2003) Genes Chromosomes Cancer, 37, 427-432. CrossRef Scholar google search
Sullivan J.P., Spinola M., Dodge M., Raso M.G., Behrens C., Gao B., Schuster K., Shao C., Larsen J.E., Sullivan L.A. et al. (2010) Cancer Res., 70, 9937-9948. CrossRef Scholar google search
Jiang F., Qiu Q., Khanna A., Todd N.W., Deepak J., Xing L., Wang H., Liu Z., Su Y., Stass S.A., Katz R.L. (2009) Mol. Cancer. Res., 7, 330-338. CrossRef Scholar google search
Shao C., Sullivan J.P., Girard L., Augustyn A., Yenerall P., Rodriguez-Canales J., Liu H., Behrens C., Shay J.W., Wistuba I.I., Minna J.D. (2014) Clin. Cancer Res., 20, 4154-4166. CrossRef Scholar google search
Chen Y., Orlicky D.J., Matsumoto A., Singh S., Thompson D.C., Vasiliou V. (2011) Biochem. Biophys. Res. Commun., 405, 173-179. CrossRef Scholar google search
Fisher G.H., Wellen S.L., Klimstra D., Lenczowski J.M., Tichelaar J.W., Lizak M.J., Whitsett J.A., Koretsky A., Varmus H.E. (2001) Genes Dev., 15, 3249-3262. CrossRef Scholar google search
McFadden D.G., Politi K., Bhutkar A., Chen F.K., Song X., Pirun M., Santiago P.M., Kim-Kiselak C., Platt J.T., Lee E., Hodges E., Rosebrock A.P., Bronson R.T., Socci N.D., Hannon G.J., Jacks T., Varmus H. (2016) Proc. Natl. Acad. Sci. USA., 113, E6409-E6417. CrossRef Scholar google search
Politi K., Zakowski M.F., Fan P.D., Schonfeld E.A., Pao W., Varmus H.E. (2006) Genes Dev., 20, 1496-1510. CrossRef Scholar google search
Tanaka H., Yanagisawa K., Shinjo K., Taguchi A., Maeno K., Tomida S., Shimada Y., Osada H., Kosaka T., Matsubara H., Mitsudomi T., Sekido Y., Tanimoto M., Yatabe Y., Takahashi T. (2007) Cancer Res., 67, 6007-6011. CrossRef Scholar google search
Weir B.A., Woo M.S., Getz G., Perner S., Ding L., Beroukhim R., Lin W.M., Province M.A., Kraja A., Johnson L.A. et al. (2007) Nature, 450, 893-898. CrossRef Scholar google search
Lu M., Jolly M.K., Levine H., Onuchic J.N., Ben-Jacob E. (2013) Proc. Natl. Acad. Sci. USA., 110, 18144-18149. CrossRef Scholar google search
Lazar V., Suo C., Orear C., van den Oord J., Balogh Z., Guegan J., Job B., Meurice G., Ripoche H., Calza S. et al. (2013) BMC Med. Genomics, 6, 53. CrossRef Scholar google search
Larzabal L., Nguewa P.A., Pio R., Blanco D., Sanchez B., Rodríguez M.J., Pajares M.J., Catena R., Montuenga L.M., Calvo A. (2011) Br. J. Cancer., 105, 1608-1614. CrossRef Scholar google search
Hu Z., Lin D., Yuan J., Xiao T., Zhang H., Sun W., Han N., Ma Y., Di X., Gao M., Ma J., Zhang J., Cheng S., Gao Y. (2005) Clin. Cancer Res., 11, 4646-4652. CrossRef Scholar google search
Sauter W., Rosenberger A., Beckmann L., Kropp S., Mittelstrass K., Timofeeva M., Wölke G., Steinwachs A., Scheiner D., Meese E., Sybrecht G., Kronenberg F., Dienemann H., LUCY-Consortium et al. (2008) Cancer Epidemiol. Biomarkers Prev., 17, 1127-1135. CrossRef Scholar google search
Ono S., Tanaka T., Ishida M., Kinoshita A., Fukuoka J., Takaki M., Sakamoto N., Ishimatsu Y., Kohno S., Hayashi T et al. (2011) Eur. Respir. J., 38, 861-869. CrossRef Scholar google search
Kim S.H., Chen G., Jeon C.K., Zhao L., Colacino J., Rozek L.S., Christensen P.J., Beer D.G., Ramnath N. (2012) Smoking effects on CYP24A1 in lung adenocarcinoma: epigenetic changes by smoking , Proceedings: AACR 103rd Annual meeting 2012, pp. 3124. Scholar google search
Kalari K.R., Rossell D., Necela B.M., Asmann Y.W., Nair A., Baheti S., Kachergus J.M., Younkin C.S., Baker T., Carr J.M. et al. (2012) Front. Oncol., 2, 12. CrossRef Scholar google search
Ozawa H., Mutai H., Matsunaga T., Tokumaru Y., Fujii M., Sakamoto K., Tomita T., Ogawa K. (2009) Anticancer Res., 29, 1981-1985. Scholar google search
Princen F., Robe P., Gros D., Jarry-Guichard T., Gielen J., Merville M.P., Bours V. (2001) Carcinogenesis, 22, 507-513. CrossRef Scholar google search
Sentani K., Oue N., Sakamoto N., Anami K., Naito Y., Aoyagi K., Sasaki H., Yasui W. (2010) Pathobiology, 77, 241-248. CrossRef Scholar google search
