Fibroblast growth factors and their effects in pancreas organogenesis

Gnatenko D.A.1 , Kopantzev E.P.1, Sverdlov E.D.1

1. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia
Section: Review
DOI: 10.18097/PBMC20176303211      PubMed Id: 28781254
Year: 2017  Volume: 63  Issue: 3  Pages: 211-218
Fibroblast growth factors (FGF) – growth factors that regulate many important biological processes, including proliferation and differentiation of embryonic cells during organogenesis. In this review, we will summarize current information about the involvement of FGFs in the pancreas organogenesis. Pancreas organogenesis is a complex process, which involves constant signaling from mesenchymal tissue. This orchestrates the activation of various regulator genes at specific stages, determining the specification of progenitor cells. Alterations in FGF/FGFR signaling pathway during this process lead to incorrect activation of the master genes, which leads to different pathologies during pancreas development. Understanding the full picture about role of FGF factors in pancreas development will make it possible to more accurately understand their role in other pathologies of this organ, including carcinogenesis.
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Keywords: growth factors, pancreas, master genes, organogenesis, pancreas tumors

Gnatenko, D. A., Kopantzev, E. P., Sverdlov, E. D. (2017). Fibroblast growth factors and their effects in pancreas organogenesis. Biomeditsinskaya Khimiya, 63(3), 211-218.
This paper is also available as the English translation: 10.1134/S1990750817040023
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