Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus

Shpakov A.O.1

1. I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Russia
Section: Review
DOI: 10.18097/PBMC20176303219      PubMed Id: 28781255
Year: 2017  Volume: 63  Issue: 3  Pages: 219-231
Thyroid diseases are closely associated with the development of types 1 and 2 diabetes mellitus (DM), and as a consequence, the development of effective approaches for their treatment is one of the urgent problems of endocrinology. Traditionally, thyroid hormones (TH) are used to correct functions of the thyroid system. However, they are characterized by many side effects, such as their negative effect on the cardiovascular system as well as the ability of TH to enhance insulin resistance and to disturb insulin-producing function of pancreas, exacerbating thereby diabetic pathology. Therefore, the analogues of TH, selective for certain types of TH receptors, that do not have these side effects, are being developed. The peptide and low-molecular weight regulators of thyroid-stimulating hormone receptor, which regulate the activity of the thyroid axis at the stage of TH synthesis and secretion in thyrocytes, are being created. Systemic and intranasal administration of insulin, metformin therapy and drugs with antioxidant activity are effective for the treatment of thyroid pathology in types 1 and 2 DM. In the review, the literature data and the results of own investigations on pharmacological approaches for the treatment and prevention of thyroid diseases in patients with types 1 and 2 DM are summarized and analyzed.
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Keywords: thyroid pathology, diabetes mellitus, thyroid hormones, low-molecular regulators, intranasally administered insulin, insulin resistance

Shpakov, A. O. (2017). Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus. Biomeditsinskaya Khimiya, 63(3), 219-231.
This paper is also available as the English translation: 10.1134/S1990750817040059
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