Metabolomic blood test: purpose, implementation and interpretation of data

Lokhov P.G.1, Lisitsa A.V.1, Archakov A.I.1

1. Institute of Biomedical Chemistry, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20176303232      PubMed Id: 28781256
Year: 2017  Volume: 63  Issue: 3  Pages: 232-240
The human body is an open system that receives a variety of xenobiotics in the course of dietary route or respiration and in the form of the drugs. As a lump sum scores of toxic and potentially toxic substances are detected in a human body that significantly affect health and human lifespan. There are also thousands of diseases, dozens of which latently occur in the body of each person. Traditional diagnosis is not able to screen all the variety of xenobiotics and potential human diseases. For this purpose metabolomic blood test is available which is of non-targeted (review) nature. The test can reveal all the diversity of low molecular weight substances in blood, including tens of thousands of xenobiotics and markers of different diseases. Detection of xenobiotics in the blood, directional detoxification and subsequent monitoring of “body's chemical purity” together with the control of “normality” of all biochemical processes in the organism, using metabolomics blood tests is a necessary and presumably a sufficient condition in the implementation of inherent human genotype longevity. This article describes the purpose, implementation and interpretation of metabolomic blood test facilitating the implementation of this method in the Russian Federation, in order to significantly increase the average life expectancy.
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Keywords: diagnosis, treatment personalization, metabolomics, metabotype, blood plasma, mass spectrometry, xenobiotics, toxicology

Lokhov, P. G., Lisitsa, A. V., Archakov, A. I. (2017). Metabolomic blood test: purpose, implementation and interpretation of data. Biomeditsinskaya Khimiya, 63(3), 232-240.
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