Abnormalities in energy metabolism and endothelial dysfunction contribute to signaling processes associated with atherogenesis. The goal of our study was to develop diagnostic tests based on endothelial functional markers and adiponectin to differentiate early stages of coronary lesions during atherogenesis. The cohort included male and female patients from 25 to 86 years of age. All subjects underwent coronary angiography and severity of coronary lesions was quantified by the Gensini score that assigns points depending on location and extent of the lesions. We have estimated associations between the Gensini score and some known primary and secondary diagnostic parameters and have found that the ratio of serum levels of adiponectin to endothelin strongly correlates with severity of coronary lesions and can be used for differentiation of male patients lacking coronary atherosclerosis (despite symptoms of ischemic heart disease) from patients that have severe coronary lesions. Predictive power of adiponectin to endothelin ratio did not depend on drug therapy.
Download PDF:
Keywords: biomarkers, endothelin, stable metabolites of nitric oxide, adiponectin, atherosclerosis
Gumanova N.G. et al. Combined markers of initial stages of coronary atherosclerosis // Biomeditsinskaya Khimiya. - 2017. - V. 63. -N 3. - P. 272-277.
Gumanova N.G. et al., "Combined markers of initial stages of coronary atherosclerosis." Biomeditsinskaya Khimiya 63.3 (2017): 272-277.
Gumanova, N. G., Klimushina, M. V., Gavrilova, N. E., Metelskaya, V. A. (2017). Combined markers of initial stages of coronary atherosclerosis. Biomeditsinskaya Khimiya, 63(3), 272-277.
References
Halcox J.P., Schenke W.H., Zalos G., Mincemoyer R., Prasad A., Waclawiw M.A., Nour K.R., Quyyumi A.A. (2002) Circulation, 106, 653-658. CrossRef Scholar google search
Bugiardini R., Manfrini O., Pizzi C., Fontana F., Morgagni G. (2004) Circulation, 109, 2518-2523. CrossRef Scholar google search
Versari D., Daghini E., Virdis A., Ghiadoni L., Taddei S. (2009) Br. J. Pharmacol., 157(4), 527-536. CrossRef Scholar google search
Dessein P.H., Tsang L., Solomon A., Woodiwiss A.J., Millen A.M., Norton G.R. (2014) Mediators of Inflammation, 5, Article ID 358949. Scholar google search
Ebrahimi-Mamaeghani M., Mohammadi S., Arefhosseini S.R., Fallah P., Bazi Z. (2015) Vascular Health and Risk Management, 11, 55-70. Scholar google search
