Production of adrenal steroid hormones in pubertal male Wistar rats exposed to low doses of DDT during both prenatal and postnatal and only postnatal development was evaluated. Altered production of all types of steroid hormones and serum steroid profile with opposite changes in rats exposed prenatally and postnatally, and only postnatally was found. The study showed that daily exposure to low doses of DDT enhanced conversion of progesterone to 17OH-progesterone and did not exert selective antiandrogenic or proestrogenic action unlike effect of toxic and subtoxic doses. Impaired morphogenesis of the adrenal cortex and circulatory disorders in zona glomerulosa contributed to reduced aldosterone and sex steroid hormones production.
Yaglova N.V. et al. Differences in adrenal steroid hormones production in pubertal rats exposed to low doses of endocrine disruptor DDT during prenatal and postnatal development // Biomeditsinskaya khimiya. - 2017. - V. 63. -N 4. - P. 306-311.
Yaglova N.V. et al., "Differences in adrenal steroid hormones production in pubertal rats exposed to low doses of endocrine disruptor DDT during prenatal and postnatal development." Biomeditsinskaya khimiya 63.4 (2017): 306-311.
Yaglova, N. V., Tsomartova, D. A., Yaglov, V. V. (2017). Differences in adrenal steroid hormones production in pubertal rats exposed to low doses of endocrine disruptor DDT during prenatal and postnatal development. Biomeditsinskaya khimiya, 63(4), 306-311.
State of the Science of Endocrine Disrupting Chemicals – 2012. (2013) An assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme (UNEP) and WHO, 296p. Scholar google search
Possible developmental early effects of endocrine disrupters on child health. (2012) WHO, 84p. Scholar google search
Diamanti-Kandarakis E., Bourguignon J.-P., Guidice L., Hauser R., Prins G., Soto A., Zoeller T., Gore A. (2009) Endocrine Rev., 30, 293-342. CrossRef Scholar google search
Lindhe O., Skogseid B., Brandt I. (2002) J. Clin. Endocrinol. Metab., 87, 1319-1326. Scholar google search
Vandenberg L., Colborn T., Hayes T., Heindel J., Jacobs D. Jr., Lee D.-H., Shioda T., Soto A., vom Saal F., Welshons W., Zoeller T., Myers J. (2012) Endocrine Rev., 33, 378-455. CrossRef Scholar google search