Features of the urine peptidome under the condition of hypertensive pathologies of pregnancy

   
Sergeeva V.A.1, Muminova K.T.2, Starodubtseva N.L.3, Kononikhin A.S.3 , Bugrova A.E.4, Indeykina M.I.5, Baibakova V.V.6, Khodzhaeva Z.S.2, Kan N.E.2, Frankevich V.E.2, Shmakov R.G.2, Nikolaev E.N.7, Sukhikh G.T.2

1. Moscow Institute of Physics and Technology, Moscow, Russia; Emanuel Institute for Biochemical Physics, Moscow, Russia
2. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
3. Moscow Institute of Physics and Technology, Moscow, Russia; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
4. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia; Emanuel Institute for Biochemical Physics, Moscow, Russia
5. Emanuel Institute for Biochemical Physics, Moscow, Russia; Talrose Institute for Energy Problems of Chemical Physics, Moscow, Russia
6. Moscow Institute of Physics and Technology, Moscow, Russia
7. Moscow Institute of Physics and Technology, Moscow, Russia; Talrose Institute for Energy Problems of Chemical Physics, Moscow, Russia
Section: OMICS-Technologies
DOI: 10.18097/PBMC20176305379      PubMed Id: 29080868
Year: 2017  Volume: 63  Issue: 5  Pages: 379-384
In order to find a peptide panel to differentiate close hypertensive conditions a case-control study was designed for 64 women from 4 groups: preeclampsia (PE), chronic hypertension superimposed with PE, chronic hypertension, and healthy individuals. Chromatography coupled with mass-spectrometry and subsequent bioinformatic analysis showed several patterns in the changes of the urine peptidome. There were 36 peptides common for four groups. Twenty two of them 22 belonged to alpha-1-chain of collagen I, nine peptides were from alpha-1-chain of collagen III, two from alpha-2-chain of collagen I, one from alpha-1/2-chain of collagen I, one from alpha-1-chain of collagen I/XVIII and one from uromodulin. Patients with hypertensive disorders had 34 common peptides: 12 from alpha-1-chain of collagen I, 10 from fibrinogen alpha-chain, eight from alpha-1-chain of collagen III, and 4 per other types of collagen. Comparative analysis revealed 12 peptides, which could be used as a diagnostic panel for confident discrimination of pregnant women with various hypertensive disorders.
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Sergeeva V.A., Muminova K.T., Starodubtseva N.L., Kononikhin A.S., Bugrova A.E., Indeykina M.I., Baibakova V.V., Khodzhaeva Z.S., Kan N.E., Frankevich V.E., Shmakov R.G., Nikolaev E.N., Sukhikh G.T. (2017) Biomeditsinskaya khimiya, 63(5), 379-384.
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