1. Mechnikov North-West State Medical University, Saint-Petersburg, Russia 2. Pavlov Institute of Physiology, St. Petersburg, Russia 3. Kirov Military Medical Academy, St. Petersburg, Russia
Synaptic pruning is a physiological mechanism of neuroplasticity, which is regulated through synthesis of growth polypeptides, neurotrophins. The role of neurotrophins in the mechanism of synaptic pruning in patients with hereditary pathology of peripheral motor neuron was studied in a clinical experimental trial. It was found that patients had elevated levels of regulatory growth polypeptides, which led to the axon growth inhibition effect in organotypic tissue cultures. Thus, neurotrophin overexpression can be considered as a factor preventing synaptic pruning and contributing to further process of neurological degeneration in nerve tissue in patients with hereditary pathology of peripheral motor neuron.
Sokolova M.G., Lobzin S.V., Penniyaynen V.A., Kipenko A.V., Lopatina E.V., Rezvantsev M.V., Gavrichenko A.V. (2017) The role of polypeptide compounds in mechanism of CNS plasticity in patients with hereditary pathology of peripheral motor neuron. Biomeditsinskaya Khimiya, 63(5), 453-456.
Sokolova M.G. et al. The role of polypeptide compounds in mechanism of CNS plasticity in patients with hereditary pathology of peripheral motor neuron // Biomeditsinskaya Khimiya. - 2017. - V. 63. -N 5. - P. 453-456.
Sokolova M.G. et al., "The role of polypeptide compounds in mechanism of CNS plasticity in patients with hereditary pathology of peripheral motor neuron." Biomeditsinskaya Khimiya 63.5 (2017): 453-456.
Sokolova, M. G., Lobzin, S. V., Penniyaynen, V. A., Kipenko, A. V., Lopatina, E. V., Rezvantsev, M. V., Gavrichenko, A. V. (2017). The role of polypeptide compounds in mechanism of CNS plasticity in patients with hereditary pathology of peripheral motor neuron. Biomeditsinskaya Khimiya, 63(5), 453-456.
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