The role of polypeptide compounds in mechanism of CNS plasticity in patients with hereditary pathology of peripheral motor neuron

   
Sokolova M.G.1 , Lobzin S.V.1, Penniyaynen V.A.2, Kipenko A.V.2, Lopatina E.V.2, Rezvantsev M.V.3, Gavrichenko A.V.1

1. Mechnikov North-West State Medical University, Saint-Petersburg, Russia
2. Pavlov Institute of Physiology, St. Petersburg, Russia
3. Kirov Military Medical Academy, St. Petersburg, Russia
Section: Technologies of Precision Medicine
DOI: 10.18097/PBMC20176305453      PubMed Id: 29080880
Year: 2017  Volume: 63  Issue: 5  Pages: 453-456
Synaptic pruning is a physiological mechanism of neuroplasticity, which is regulated through synthesis of growth polypeptides, neurotrophins. The role of neurotrophins in the mechanism of synaptic pruning in patients with hereditary pathology of peripheral motor neuron was studied in a clinical experimental trial. It was found that patients had elevated levels of regulatory growth polypeptides, which led to the axon growth inhibition effect in organotypic tissue cultures. Thus, neurotrophin overexpression can be considered as a factor preventing synaptic pruning and contributing to further process of neurological degeneration in nerve tissue in patients with hereditary pathology of peripheral motor neuron.
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Sokolova M.G., Lobzin S.V., Penniyaynen V.A., Kipenko A.V., Lopatina E.V., Rezvantsev M.V., Gavrichenko A.V. (2017) Biomeditsinskaya khimiya, 63(5), 453-456.
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