Participation of melatonin in regulation of blood oxygen-transport function in oxidative stress induced by injection of lipopolisaccharide

   
Zinchuk V.V.1 , Firago M.E.1

1. Grodno State Medical University, Grodno, Belarus
Section: Experimental Study
DOI: 10.18097/PBMC20176306520      PubMed Id: 29251613
Year: 2017  Volume: 63  Issue: 6  Pages: 520-526
The contribution of melatonin to the regulatoin of the blood oxygen transport function was studied during oxidative stress induced by a triple injection of lipopolysaccharide (at a dose of 5 mg/kg) in conditions of erythropoietin and gasetransmitters (nitrogen monoxide, hydrogen sulfide) action. In the experimental groups, intraperitoneal injections of melatonin (5 mg/kg), erythropoietin (1000 U/kg), hydrogen sulfide donor (NaHS 5 mg/kg), and L-arginine (100 mg/kg), were performed. The use of melatonin alone or in combination with erythropoietin, sodium hydrosulfide or L-arginine led to a decrease in lipid peroxidation products and an increase in the antioxidant protection. Melatonin, during lipopolysaccharide administration, caused changes of blood oxygen transport function: blood oxygen saturation increased, hemoglobin oxygen affinity increased. The modifying effect of melatonin on the blood oxygen transport function in combination with erythropoietin and gastransmitters did not exceed the effect of melatonin alone.
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Keywords: lipopolysaccharide, oxidative stress, blood, melatonin, erythropoietin, gastransmitters, nitrogen monoxide, hydrogen sulfide
Citation:

Zinchuk, V. V., Firago, M. E. (2017). Participation of melatonin in regulation of blood oxygen-transport function in oxidative stress induced by injection of lipopolisaccharide. Biomeditsinskaya khimiya, 63(6), 520-526.
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