Disorders in structural-functional properties of erythrocytes in experimental acute destructive pancreatitis of alcohol etiology and their correction

   
Konoplja A.I.1, Litvinova E.S.1, Sunyaykina O.A.1 , Bushmina O.N.1, Harchenko A.V.1, Konoplja A.A.1

1. Kursk State Medical University, Kursk, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20176306527      PubMed Id: 29251614
Year: 2017  Volume: 63  Issue: 6  Pages: 527-532
The effects of various combinations of pharmacological agents on parameters characterizing red blood cell (RBC) membrane proteins and lipids have been investigated in RBC isolated from Wistar male rats with acute destructive pancreatitis induced under conditions of forced alcoholization for 60 days. Administration of a combination of Hepon, Hypoxenum, and Phosphogliv normalized 22.5% of parameters altered change during development of acute destructive pancreatitis under conditions of chronic alcoholization of parameters, corrected towards normal values 42.5% of parameters (35% of parameters remained unchanged). Administration of Glutoxim, Mexidol and Heptral, was more effective: this combination normalized 50.0% of parameters studied, corrected towards normal values 37.5% of parameters, leaving unchanged only 12.5% of parameters studied.
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Keywords: experimental acute destructive pancreatitis, ethanol, structural-functional properties, pharmacological correction
Citation:

Konoplja, A. I., Litvinova, E. S., Sunyaykina, O. A., Bushmina, O. N., Harchenko, A. V., Konoplja, A. A. (2017). Disorders in structural-functional properties of erythrocytes in experimental acute destructive pancreatitis of alcohol etiology and their correction. Biomeditsinskaya khimiya, 63(6), 527-532.
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