Evaluation of adjuvant effects of fucoidane from brown seaweed Fucus evanescens and its structural analogues for the strengthening vaccines effectiveness
1. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia; Far Eastern Federal University, Vladivostok, Russia 2. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia 3. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia 4. Far Eastern Federal University, Vladivostok, Russia
The use of sulfated polysaccharides from brown seaweed Fucus evanescens as adjuvants (native fucoidan in combination with polyphenols, fucoidan without polyphenols, a product of enzymatic hydrolysis of fucoidan) stimulated the formation of specific antibodies to the surface antigen of the hepatitis B virus (HBs-AG). Immunization of mice with vaccine compositions containing HBs-AG and fucoidan samples resulted in increasing the serum level of the pro-inflammatory (TNF-a, IFN-g, IL-2) cytokines. Increased production of these cytokines was detected in the culture of splenocytes additionally stimulated in vitro by fucoidans or phytohemagglutinin. The adjuvant effect of fucoidan and its structural modifications was comparable to that of the traditional licensed adjuvant aluminum hydroxide. The obtained results indicate a promising use of sulfated polysaccharides from F. evanescens as vaccine adjuvants.
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Keywords: sulfated polysaccharides, fucoidans, vaccines adjuvants, immunity, cytokines, hepatitis B
Citation:
Kuznetsova T.A., Ivanushko L.A., Persiyanova E.V., Shutikova A.L., Ermakova S.P., Khotimchenko M.Yu., Besednova N.N. (2017) Evaluation of adjuvant effects of fucoidane from brown seaweed Fucus evanescens and its structural analogues for the strengthening vaccines effectiveness. Biomeditsinskaya Khimiya, 63(6), 553-558.
Kuznetsova T.A. et al. Evaluation of adjuvant effects of fucoidane from brown seaweed Fucus evanescens and its structural analogues for the strengthening vaccines effectiveness // Biomeditsinskaya Khimiya. - 2017. - V. 63. -N 6. - P. 553-558.
Kuznetsova T.A. et al., "Evaluation of adjuvant effects of fucoidane from brown seaweed Fucus evanescens and its structural analogues for the strengthening vaccines effectiveness." Biomeditsinskaya Khimiya 63.6 (2017): 553-558.
Kuznetsova, T. A., Ivanushko, L. A., Persiyanova, E. V., Shutikova, A. L., Ermakova, S. P., Khotimchenko, M. Yu., Besednova, N. N. (2017). Evaluation of adjuvant effects of fucoidane from brown seaweed Fucus evanescens and its structural analogues for the strengthening vaccines effectiveness. Biomeditsinskaya Khimiya, 63(6), 553-558.
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