Comparative sub-population analysis of exosomes from blood plasma of cancer patients

   
Tamkovich S.N.1 , Yunusova N.V.2, Somov A.K.3, Kakurina G.V.2, Kolegova E.S.2, Tugurova E.A.2, Laktionov P.P.3, Kondakova I.V.2

1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia
2. Tomsk Cancer Research Institute, Tomsk, Russia
3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
Section: Review
DOI: 10.18097/PBMC20186401110      PubMed Id: 29460840
Year: 2018  Volume: 64  Issue: 1  Pages: 110-114
To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles is required. In the present work, universal proteins have been identified, their expression has been increased in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will further develop a simple and high-performance method of affinity isolation of tumor exosomes.
Download PDF:
Keywords: exosomes, transmission electron microscopy, flow cytometry, proteins, colorectal cancer, head and neck squamous cell carcinoma, lung cancer
Citation:

Tamkovich, S. N., Yunusova, N. V., Somov, A. K., Kakurina, G. V., Kolegova, E. S., Tugurova, E. A., Laktionov, P. P., Kondakova, I. V. (2018). Comparative sub-population analysis of exosomes from blood plasma of cancer patients. Biomeditsinskaya khimiya, 64(1), 110-114.
This paper is also available as the English translation: 10.1134/S1990750818020130
References  
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)