The effect of the biologically active additive epiphamine on antioxidant and NADPH-generating enzymes activity under experimental cerebral ischemia/reperfusion in rats
The effect of biologically active additive with immunomodulator properties epiphamine on the activity of antioxidant (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase) and NADPH-generating (glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase) enzymes has been investigated at experimental cerebral ischemia/reperfusion in rats. The results obtained indicate epiphamine-induced changes of these enzymes activities towards control values. Changes in the content of lactate, a marker of the pathology development, have also been found in experimental animals under ischemia and epiphamine administration caused changes similar to those observed in the case of enzyme activities studied. In most cases, the changes were dose-dependent. Thus, epiphamine can be of considerable interest from the point of view of metabolic changes pharmacological correction at the development of the pathology accompanied by oxidative stress.
Popova T.N., Safonova O.A., Stolyarova A.O., Verevkin A.N. (2018) The effect of the biologically active additive epiphamine on antioxidant and NADPH-generating enzymes activity under experimental cerebral ischemia/reperfusion in rats. Biomeditsinskaya Khimiya, 64(1), 31-37.
Popova T.N. et al. The effect of the biologically active additive epiphamine on antioxidant and NADPH-generating enzymes activity under experimental cerebral ischemia/reperfusion in rats // Biomeditsinskaya Khimiya. - 2018. - V. 64. -N 1. - P. 31-37.
Popova T.N. et al., "The effect of the biologically active additive epiphamine on antioxidant and NADPH-generating enzymes activity under experimental cerebral ischemia/reperfusion in rats." Biomeditsinskaya Khimiya 64.1 (2018): 31-37.
Popova, T. N., Safonova, O. A., Stolyarova, A. O., Verevkin, A. N. (2018). The effect of the biologically active additive epiphamine on antioxidant and NADPH-generating enzymes activity under experimental cerebral ischemia/reperfusion in rats. Biomeditsinskaya Khimiya, 64(1), 31-37.
References
Ortiz G.G., Pacheco Moisés F.P., Mireles-Ramírez M., Flores-Alvarado L.J., González-Usigli H., Sánchez-González V.J., Sánchez-López A.L., Sánchez-Romero L., Díaz-Barba E.I., Santoscoy-Gutiérrez J.F., Rivero-Moragrega P. (2017) Adv. Protein Chem. Struct. Biol., 108, 1-31. CrossRef Scholar google search
Bavithra S., Selvakumar K., Krishnamoorthy G., Venkataraman P., Arunakaran J. (2013) Environmen. Toxicol. Pharmacol., 36(1), 152-163. CrossRef Scholar google search
Lekic T., Hartman R., Rojas H., Manaenko A., Chen W., Ayer R., Tang J., Zhang J.H. (2010) J. Neurotrauma, 27(3), 627-637. CrossRef Scholar google search
De Carvalho M.A.A., Popov S.S., Safonova O.A., Makeeva A.V., Matasova L.V., Popova T.N., Pashkov A.N. (2010) The effects of some substances-protectors on free-radical homeostasis in diseases with oxidative stress, Handbook of Free Radicals: Formation, Types and Effects, Nova Science Publishers, Inc., New York, pp. 291-303. Scholar google search
Nam H.Y., Choi B.H., Lee J.Y., Lee S.G., Kim Y.H., Lee K.H., Yoon H.K., Song J.S., Kim H.J., Lim Y. (2004) Toxicol. Letts., 148(1), 95-102. CrossRef Scholar google search
