Pharmacological targets for dislipidemies correction. Opportunities and prospects of therapeutic usage

   
Kudinov V.A.1, Zakharova T.S.1 , Torkhovskaya T.I.1, Ipatova O.M.1, Archakov A.I.1

1. Institute of Biomedical Chemistry, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20186401066      PubMed Id: 29460837
Year: 2018  Volume: 64  Issue: 1  Pages: 66-83
Literature data on influence of existing and new groups of drug preparations for dyslipidemias correction are systemized, and molecular mechanisms of their effects are reviewed. The results of experimental and clinical investigations aimed at revealing of new pharmacological targets of dyslipidemias correction were analyzed. The approaches for activation of high density lipoproteins functionality are described. The implementation of alternative preparations with new alternative mechanisms of action may be suggested to improve the effectiveness of traditional treatment in the future.
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Keywords: cholesterol, atherosclerosis, high density lipoproteins, reverse cholesterol transport, macrophages, hypolipidemic drugs
Citation:

Kudinov, V. A., Zakharova, T. S., Torkhovskaya, T. I., Ipatova, O. M., Archakov, A. I. (2018). Pharmacological targets for dislipidemies correction. Opportunities and prospects of therapeutic usage. Biomeditsinskaya khimiya, 64(1), 66-83.
This paper is also available as the English translation: 10.1134/S1990750818020075
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