Phospholipase D: its role in metabolism processes and disease development
Ramenskaia G.V.1, Melnik E.V.1, Petukhov A.E.2
1. Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia 2. Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia; Moscow Research and Practical Centre for Narcology, Moscow, Russia
Phospholipase D (PLD) is one of the key enzymes that catalyzes the hydrolysis of cell membrane phospholipids. In this review current knowledge about six human PLD isoforms, their structure and role in physiological and pathological processes is summarized. Comparative analysis of PLD isoforms structure is presented. The mechanism of the hydrolysis and transphosphatidylation performed by PLD is described. The PLD1 and PLD2 role in the pathogenesis of some cancer, infectious, thrombotic and neurodegenerative diseases is analyzed. The prospects of PLD isoform-selective inhibitors development are shown in the context of the clinical usage and the already-existing inhibitors are characterized. Moreover, the formation of phosphatidylethanol (PEth), the alcohol abuse biomarker, as the result of PLD-catalyzed phospholipid transphosphatidylation is considered.
Download PDF:
Keywords: phospholipase D (PLD), phospholipase D isoforms, phospholipase D inhibitors, phosphatidylethanol (PEth), alcohol abuse biomarkers
Citation:
Ramenskaia G.V., Melnik E.V., Petukhov A.E. (2018) Phospholipase D: its role in metabolism processes and disease development. Biomeditsinskaya Khimiya, 64(1), 84-93.
Ramenskaia G.V. et al. Phospholipase D: its role in metabolism processes and disease development // Biomeditsinskaya Khimiya. - 2018. - V. 64. -N 1. - P. 84-93.
Ramenskaia G.V. et al., "Phospholipase D: its role in metabolism processes and disease development." Biomeditsinskaya Khimiya 64.1 (2018): 84-93.
Ramenskaia, G. V., Melnik, E. V., Petukhov, A. E. (2018). Phospholipase D: its role in metabolism processes and disease development. Biomeditsinskaya Khimiya, 64(1), 84-93.
Stahelin R.V., Ananthanarayanan B., Blatner N.R., Singh S., Bruzik K.S., Murray D., Cho W. (2004) J. Biol. Chem., 279, 54918-54926. CrossRef Scholar google search
Yoshikawa F., Banno Y., Otani Y., Yamaguchi Y., Nagakura-Takagi Y., Morita N., Sato Y., Saruta C., Nishibe H., Sadakata T. et al. (2010) PLoS One, 5, e13932. CrossRef Scholar google search
Cruchaga C., Karch C.M., Jin S.C., Benitez B.A., Cai Y., Guerreiro R., Harari O., Norton J., Budde J., Bertelsen S. et al. (2014) Nature, 505, 550-554. CrossRef Scholar google search
Otani Y., Yamaguchi Y., Sato Y., Furuichi T., Ikenaka K., Kitani H., Baba H. (2011) PloS One, 6, e27544. CrossRef Scholar google search
Zhang Y., Liu X., Bai J., Tian X., Zhao X., Liu W., Duan X., Shang W., Fan H.Y., Tong C. (2016) Mol. Cell, 61, 111-124. CrossRef Scholar google search
Baba T., Kashiwagi Y., Arimitsu N., Kogure T., Edo A., Maruyama T., Nakao K., Nakanishi H., Kinoshita M., Frohman M.A., Yamamoto A., Tani K. (2014) J. Biol. Chem., 289, 11497-11511. CrossRef Scholar google search
Huang H., Gao Q., Peng X., Choi S.Y., Sarma K., Ren H., Morris A.J., Frohman M.A. (2011) Dev. Cell, 20, 376-387. CrossRef Scholar google search
Patil A.A., Tatsuke T., Mon H., Lee J.M., Morokuma D., Hino M., Kusakabe T. (2017) Biochem. Biophys. Res. Commun., 493(2), 971-978. CrossRef Scholar google search
Nishimasu H., Ishizu H., Saito K., Fukuhara S., Kamatani M.K., Bonnefond L., Matsumoto N., Nishizawa T., Nakanaga K., Aoki J. et al. (2012) Nature, 491, 284-287. CrossRef Scholar google search
Monovich L., Mugrage B., Quadros E., Toscano K., Tommasi R., LaVoie S., Liu E., Du Z., LaSala D., Boyar W., Steed P. (2007) Bioorg. Med. Chem. Lett., 17, 2310-2311. CrossRef Scholar google search
Su W., Yeku O., Olepu S., Genna A., Park J.S., Ren H., Du G., Gelb M.H., Morris A.J., Frohman M.A. (2009) Mol. Pharmacol., 75, 437-446. CrossRef Scholar google search
Scott S.A., Selvy P.E., Buck J.R., Cho H.P., Criswell T.L., Thomas A.L., Armstrong M.D., Arteaga C.L., Lindsley C.W., Brown H.A. (2009) Nat. Chem. Biol., 5, 108-117. CrossRef Scholar google search
Kulkarni A., Quang P., Curry V., Keyes R., Zhou W., Cho H., Baffoe J., Török B., Stieglitz K. (2014) Chem. Biol. Drug Des., 84, 270-281. CrossRef Scholar google search
Norton L.J., Zhang Q., Saqib K.M., Schrewe H., Macura K., Anderson K.E., Lindsley C.W., Brown H.A., Rudge S.A., Wakelam M.J. (2011) J. Cell Sci., 124, 1973-1983. CrossRef Scholar google search
Dhingra S., Rodriguez M.E., Shen Q., Duan X., Stanton M.L., Chen L., Zhang R., Brown R.E. (2010) Int. J. Clin. Exp. Pathol., 4, 134-146. Scholar google search
Chen Q., Hongu T., Sato T., Zhang Y., Ali W., Cavallo J.A., van der Velden A., Tian H., Di Paolo G., Nieswandt B., Kanaho Y., Frohman M.A. (2012) Sci Signal., 5, ra79, DOI: 10.1126/scisignal.2003257. CrossRef Scholar google search
Ghim J., Moon J.S., Lee C.S., Lee J., Song P., Lee A., Jang J.H., Kim D., Yoon J.H., Koh Y.J. et al. (2014) Arterioscler. Thromb. Vasc. Biol., 34, 1697-1703. CrossRef Scholar google search
Choi J.W., Herr D.R., Noguchi K., Yung Y.C., Lee C.W., Mutoh T., Lin M.E., Teo S.T., Park K.E., Mosley A.N., Chun J. (2010) Annu. Rev. Pharmacol. Toxicol., 50, 157-186. CrossRef Scholar google search
Karlas A., Machuy N., Shin Y., Pleissner K.P., Artarini A., Heuer D., Becker D., Khalil H., Ogilvie L.A., Hess S., Mäurer A.P., Müller E., Wolff T., Rudel T., Meyer T.F. (2010) Nature, 463, 818-822. CrossRef Scholar google search
Oguin T.H. 3rd, Sharma S., Stuart A.D., Duan S., Scott S.A., Jones C.K., Daniels J.S., Lindsley C.W., Thomas P.G., Brown H.A. (2014) J. Biol. Chem., 289, 25405-25417. CrossRef Scholar google search
Ali W.H., Chen Q., Delgiorno K.E., Su W., Hall J.C., Hongu T., Tian H., Kanaho Y., Di Paolo G., Crawford H.C., Frohman M.A. (2013) PLoS One, 8, e55325. CrossRef Scholar google search
Elvers M., Stegner D., Hagedorn I., Kleinschnitz C., Braun A., Kuijpers M.E., Boesl M., Chen Q., Heemskerk J.W., Stoll G., Frohman M.A., Nieswandt B. (2010) Sci. Signal., 3, ra1, DOI: 10.1126/scisignal.2000551. CrossRef Scholar google search
Thielmann I., Stegner D., Kraft P., Hagedorn I., Krohne G., Kleinschnitz C., Stoll G., Nieswandt B. (2012) J. Thromb. Haemost., 10, 2361-2372. CrossRef Scholar google search
Stegner D., Thielmann I., Kraft P., Frohman M.A., Stoll G., Nieswandt B. (2013) Arterioscler. Thromb. Vasc. Biol., 33, 2212-2217. CrossRef Scholar google search
Taylor H.E., Simmons G.E. Jr., Mathews T.P., Khatua A.K., Popik W., Lindsley C.W., D'Aquila R.T., Brown H.A. (2015) PLoS Pathog., 11(5), e1004864. CrossRef Scholar google search