Phospholipase D: its role in metabolism processes and disease development
Ramenskaia G.V.1, Melnik E.V.1, Petukhov A.E.2
1. Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia 2. Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia; Moscow Research and Practical Centre for Narcology, Moscow, Russia
Phospholipase D (PLD) is one of the key enzymes that catalyzes the hydrolysis of cell membrane phospholipids. In this review current knowledge about six human PLD isoforms, their structure and role in physiological and pathological processes is summarized. Comparative analysis of PLD isoforms structure is presented. The mechanism of the hydrolysis and transphosphatidylation performed by PLD is described. The PLD1 and PLD2 role in the pathogenesis of some cancer, infectious, thrombotic and neurodegenerative diseases is analyzed. The prospects of PLD isoform-selective inhibitors development are shown in the context of the clinical usage and the already-existing inhibitors are characterized. Moreover, the formation of phosphatidylethanol (PEth), the alcohol abuse biomarker, as the result of PLD-catalyzed phospholipid transphosphatidylation is considered.
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Keywords: phospholipase D (PLD), phospholipase D isoforms, phospholipase D inhibitors, phosphatidylethanol (PEth), alcohol abuse biomarkers
Citation:
Ramenskaia G.V., Melnik E.V., Petukhov A.E. (2018) Phospholipase D: its role in metabolism processes and disease development. Biomeditsinskaya Khimiya, 64(1), 84-93.
Ramenskaia G.V. et al. Phospholipase D: its role in metabolism processes and disease development // Biomeditsinskaya Khimiya. - 2018. - V. 64. -N 1. - P. 84-93.
Ramenskaia G.V. et al., "Phospholipase D: its role in metabolism processes and disease development." Biomeditsinskaya Khimiya 64.1 (2018): 84-93.
Ramenskaia, G. V., Melnik, E. V., Petukhov, A. E. (2018). Phospholipase D: its role in metabolism processes and disease development. Biomeditsinskaya Khimiya, 64(1), 84-93.
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