Features of redox processes in the amniotic fluid at placental insufficiency

Pogorelova T.N.1 , Nikashina A.A.1, Gunko V.O.1, Larichkin A.V.1, Chebotarev D.A.2

1. Scientific-Research Institute of Obstetrics and Pediatrics of Rostov State Medical University, Rostov-on-Don, Russia
2. Federal Research Centre Southern Scientific Center of Russian Academy of Sciences, Rostov-on-Don, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20186403290      PubMed Id: 29964267
Year: 2018  Volume: 64  Issue: 3  Pages: 290-297
Activity of prooxidant enzymes (NADPH-oxidase and xanthine oxidase), antioxidant enzymes (superoxide dismutase (SOD) and catalase), enzymes of the glutathione-dependent systems, as well as antioxidant vitamins (retinol and alpha-tocopherol), lipid peroxidation products (LPP) (conjugated dienes and Schiff bases), and peroxide chemiluminescence were studied in the amniotic fluid at different periods of physiological pregnancy and placental insufficiency (PI). It was found that at PI the activity of NADPH-oxidase, xanthine oxidase increased and the activity of SOD, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase and the content of fat-soluble vitamins decreased. The direct and inverse correlation between the studied pro- and antioxidant parameters and the content of LPP products, was found ro be different in the II and III trimesters of gestation. The revealed differences obviously reflect metabolic impairments in the fetoplacental complex, and the activity and level of the paremeters of redox processes can be used as tests for pre- and postnatal disorders.
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Keywords: redox balance, pro- and antioxidant enzymes, antioxidant vitamins, products of lipid peroxidation, amniotic fluid, placental insufficiency

Pogorelova, T. N., Nikashina, A. A., Gunko, V. O., Larichkin, A. V., Chebotarev, D. A. (2018). Features of redox processes in the amniotic fluid at placental insufficiency. Biomeditsinskaya Khimiya, 64(3), 290-297.
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