1. East-Siberian Institute of Medico-Ecological Researches, Angarsk, Russia; Irkutsk National Research Technical University, Irkutsk, Russia 2. East-Siberian Institute of Medico-Ecological Researches, Angarsk, Russia 3. Medical autonomous non-profit organization “Medical-diagnostic center”, Angarsk, Russia
A comparative evaluation of serum concentrations of cytokines and IgE production in patients with occupational bronchial asthma (BA) caused by exposure to the toxic-dust factor of the aluminum industry and patients with asthma of unprofessional genesis was carried out. A more pronounced pro-inflammatory response has been found in patients with occupational BA characterized by hyperproduction of IL-1b, IL-8. While for persons with non-professional asthma, a decrease in IL-1b, IL-5, IL-10 is characteristic. The common pattern of the detected changes in the patients of both groups consists in an increase in the production of IgE (6 times in patients with occupational BA and 8.9 times with non-occupational asthma) and a decrease in serum concentrations of TNF-a. Various cytokine manifestations in occupational and unprofessional BA may be associated with different etiopathogenetic mechanisms of disturbance of intra-immune regulation, and also confirms the professional conditionality of the revealed changes in patients with BA who work in the aluminum industry.
Keywords: cytokines, immunoglobulin E, professional and non-professional bronchial asthma, aluminum industry
Bodienkova G.M. et al. Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis // Biomeditsinskaya khimiya. - 2018. - V. 64. -N 4. - P. 376-379.
Bodienkova G.M. et al., "Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis." Biomeditsinskaya khimiya 64.4 (2018): 376-379.
Bodienkova, G. M., Boklazhenko, E. V., Bodienkova, S. G., Beygel, E. A. (2018). Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis. Biomeditsinskaya khimiya, 64(4), 376-379.
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