Expression of osteoprotegerin and soluble ligand of receptor of kappa-B transcription factor activator in the calcification of aortic valve

Voronkina I.V.1 , Irtyuga O.B.2, Smagina L.V.1, Adamova P.E.3, Zhiduleva E.V.2, Malashicheva A.B.2, Sibagatullina Y.S.2, Kruk L.P.4, Gordeev M.L.2, Moiseeva O.M.2

1. Institute of Cytology RAS, St. Petersburg, Russia
2. Almazov National Medical Research Centre, St. Petersburg, Russia
3. St-Petersburg State Institute of Technology, St. Petersburg, Russia
4. Faculty of Medicine, St. Petersburg State University, St. Petersburg, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20196501057      PubMed Id: 30816098
Year: 2019  Volume: 65  Issue: 1  Pages: 57-62
The mechanism of valve calcification that is the main cause of aortic stenosis formation and progression is not yet clear. In recent years, the role of the OPG/RANKL/RANK system is considered as one of possible variants of pathogenesis of valve calcification. In presented work the differences in OPG and sRANKL levels involved in the calcification processes in tissues of patients with severe aortic stenosis have been examined. The study was performed using three groups of patients: group 1 – patients with aortic stenosis, group 2 – patients with aortic aneurysm, and group 3 – patients with aortic stenosis and aortic dilatation. In patients with aortic stenosis, the level of RANKL was significantly higher, and the level of RANKL was higher in valve than in tissue. The negative correlation between aortic dilatation and RANKL level indicated the lack of RANKL influence on pathogenesis of aortic dilatation. The obtained data confirm the increased expression of RANKL in patients with aortic valve calcification. The results of this study confirm importance of the OPG/RANKL/RANK system in calcification in patients with aortic stenosis. Athough patients of all groups had comparable values of OPG (including patients with aortic dilatation), the RANKL level increased only in patients with aortic stenosis. This suggest involvement of some additional mechanisms influencing the increase of RANKL expression.
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Keywords: aortic stenosis, aortic valve calcification, OPG/RANKL/RANK system

Voronkina, I. V., Irtyuga, O. B., Smagina, L. V., Adamova, P. E., Zhiduleva, E. V., Malashicheva, A. B., Sibagatullina, Y. S., Kruk, L. P., Gordeev, M. L., Moiseeva, O. M. (2019). Expression of osteoprotegerin and soluble ligand of receptor of kappa-B transcription factor activator in the calcification of aortic valve. Biomeditsinskaya Khimiya, 65(1), 57-62.
This paper is also available as the English translation: 10.1134/S1990750819020112
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