Stability of prolin-containing peptides in biological media Shevchenko K.V.1 1 1 1 1 1. Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, Russia Section: Review DOI: 10.18097/PBMC20196503180 PubMed Id: 31258142
Year: 2019 Volume: 65 Issue : 3 Pages: 180-201in vitro experiments was determined using different commercially available peptidases (leucine aminopeptidases, dipeptidases, carboxypeptidases B and Y), and using nasal mucus, microsomal fraction of the rat brain (IMPC) and rat blood plasma. During peptidase hydrolysis of Pro-Gly-Pro-Leu, the main metabolites were Gly-Pro-Leu, Pro-Gly-Pro, Gly-Pro and Pro-Gly. For ACTH(6-9)Pro-Gly-Pro, the main metabolites were Phe-Arg-Trp-Pro-Gly-Pro and Trp-Pro-Gly-Pro. In peptidase hydrolysis of 5-oxo-Pro-His-Pro-NH2, the major metabolite was 5-oxo-Pro-His-Pro. It was shown that with different methods of peptides administration the composition of the metabolites formed is different. Based on the data obtained, resistance to enzymatic cleavage of peptides and their metabolic pathways were evaluated. Thus, these new data have shown that the above approaches can be used to prolong the action of glyprolines in living objects. In this case, the degradation of proline-containing peptides occurs mainly not due to the action of proteases, but due to other ways of degradation. In general, the data presented in the review indicate the promise of intranasal way of introducing biologically active peptides into the brain of living organisms.Download PDF: Keywords: peptides, proteolysis, methods of administration, tritium-labeled analogs, distribution in organs
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Shevchenko K.V., Nagaev I.Yu., Andreeva L.A., Shevchenko V.P., Myasoedov N.F. (2019) Stability of prolin-containing peptides in biological media. Biomeditsinskaya Khimiya, 65 (3), 180-201.
Shevchenko K.V. et al. Stability of prolin-containing peptides in biological media // Biomeditsinskaya Khimiya. - 2019. - V. 65. -N 3. - P. 180-201.
Shevchenko K.V. et al., "Stability of prolin-containing peptides in biological media." Biomeditsinskaya Khimiya 65.3 (2019): 180-201.
Shevchenko, K. V., Nagaev, I. Yu., Andreeva, L. A., Shevchenko, V. P., Myasoedov, N. F. (2019). Stability of prolin-containing peptides in biological media. Biomeditsinskaya Khimiya , 65(3), 180-201.
This paper is also available as the English translation: 10.1134/S1990750819030089
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